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Table 3 Dietary lead intake, blood lead levels, and their correlation coefficient according to the four selected SNPs analyzed via the replication study

From: Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population

SNP ID

Gene symbol

Genotype

N

Dietary Pb

Blood Pb

Spearman’s correlation coefficients

rs41268474

C1orf68

GG

1284

20.34 ± 9.21

2.21 (1.48)

0.097**

  

GA

193

20.51 ± 9.33

2.22 (1.49)

0.091

  

AA

4

28.21 ± 15.93

2.12 (1.59)

0.712

    

P = 0.960

P = 0.958

 

rs11066280

C12orf51

TT

1001

20.36 ± 9.31

2.25 (1.49)

0.103**

  

TA

433

20.38 ± 8.98

2.14 (1.46)

0.112*

  

AA

47

20.80 ± 10.49

2.04 (1.42)

−0.121

    

P = 0.951

P = 0.027

 

rs12229654

MYL2

TT

1087

20.39 ± 9.33

2.25 (1.49)

0.127

  

TG

353

20.31 ± 8.86

2.13 (1.46)

0.019

  

GG

27

19.30 ± 10.38

1.92 (1.37)

−0.220

    

P = 0.873

P = 0.015

 

rs671

ALDH2

GG

1053

20.40 ± 9.33

2.26 (1.49)

0.120**

  

GA

388

20.24 ± 8.86

2.11 (1.46)

0.064

  

AA

40

21.32 ± 10.79

1.98 (1.38)

−0.210

    

P = 0.773

P = 0.003

 
  1. *P<0.05, **P<0.01