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Table 4 Standardized path coefficients depicting the relationship between 5 chemicals, cognitive functioning and covariates for participants 60–69 and 70–84 years old, NHANES 1999-2002

From: A path analysis of multiple neurotoxic chemicals and cognitive functioning in older US adults (NHANES 1999–2002)

Path

Path coefficient (95% CI) p-value

  

Lipid-adjusted

Non-lipid-adjusted

Lipid-adjusted

Non-lipid-adjusted

Age 60-69

PCB 74 → DSC

0.01 (−0.21, 0.23)

0.001 (−0.23, 0.23)

0.92

0.99

PCB 118 → DSC

−0.10 (−0.23, 0.25)

0.02 (−0.23, 0.27)

0.93

0.89

PCB 146 → DSC

−0.20 (−0.43, 0.02)

−0.21 (−0.44, 0.03)

0.08

0.08

PCB 153 → DSC

0.28 (0.03, 0.53)

0.28 (0.02, 0.54)

0.03

0.04

Lead → DSC

−0.13 (−0.28, 0.01)

−0.13 (−0.28, 0.02)

0.07

0.08

aPIR2 → DSC

0.16 (0.03, 0.30)

0.16 (0.03, 0.29)

0.02

0.02

bPIR3 → DSC

0.33 (0.15, 0.50)

0.33 (0.15, 0.50)

<0.001

<0.001

cED2 → DSC

0.25 (0.08, 0.42)

0.25 (0.08, 0.42)

0.004

0.003

dED3 → DSC

0.28 (0.17, 0.39)

0.28 (0.17, 0.39)

<0.001

<0.001

eED4 → DSC

0.29 (0.18, 0.40)

0.29 (0.18, 0.41)

<0.001

<0.001

fMA → DSC

−0.12 (−0.20, −0.04)

−0.12 (−0.20, −0.05)

0.003

0.002

gOH → DSC

−0.12 (−0.26, 0.02)

−0.12 (−0.26, −0.02)

0.09

0.09

hNHB → DSC

−0.18 (−0.25, −0.10)

−0.18 (−0.25, −0.10)

<0.001

<0.001

Age → DSC

−0.13 (−0.24, −0.01)

−0.13 (−0.24, −0.01)

0.03

0.03

Sex → DSC

0.14 (0.05, 0.24)

0.14 (0.04, 0.23)

0.004

0.005

Smoke → DSC

0.04 (−0.11, 0.19)

0.04 (−0.11, 0.19)

0.58

0.60

Age 70–84 (N = 248)

PCB 74 → DSC

−0.02 (−0.21, 0.18)

−0.02 (−0.22, 0.18)

0.88

0.88

PCB 118 → DSC

−0.13 (−0.29, 0.03)

−0.13 (−0.31, 0.04)

0.12

0.13

PCB 146 → DSC

−0.10 (−0.41, 0.21)

−0.10 (−0.44, 0.23)

0.53

0.55

PCB 153 → DSC

0.12 (−0.14, 0.38)

0.13 (−0.16, 0.42)

0.37

0.40

Lead → DSC

−0.08 (−0.20, 0.04)

−0.08 (−0.20, 0.04)

0.19

0.17

PIR2 → DSC

0.19 (0.03, 0.35)

0.19 (0.02, 0.35)

0.02

0.03

PIR3 → DSC

0.26 (0.11, 0.42)

0.26 (0.10, 0.41)

0.001

0.001

ED2 → DSC

0.25 (0.12, 0.39)

0.25 (0.12, 0.39)

<0.001

<0.001

ED3 → DSC

0.18 (0.04, 0.32)

0.18 (0.03, 0.32)

0.01

0.02

ED4 → DSC

0.30 (0.18, 0.42)

0.31 (0.19, 0.42)

<0.001

<0.001

MA → DSC

−0.11 (−0.18, −0.05)

−0.11 (−0.17, −0.05)

<0.001

<0.001

OH → DSC

−0.20 (−0.32, −0.09)

−0.20 (−0.31, −0.09)

<0.001

<0.001

NHB → DSC

−0.17 (−0.27, −0.07)

−0.18 (−0.27, −0.08)

<0.001

<0.001

Age → DSC

−0.22 (−0.30, −0.10)

−0.20 (−0.30, −0.10)

<0.001

<0.001

Sex → DSC

0.10 (−0.04, 0.24)

0.11 (−0.04, 0.25)

0.15

0.15

Smoke → DSC

−0.06 (−0.18, 0.07)

−0.06 (−0.18, 0.07)

0.35

0.37

  1. a PIR2 2nd Tertile Poverty Index Ratio
  2. b PIR2 3 nd Tertile Poverty Index Ratio
  3. c Ed2 High School Grad/GED
  4. d Ed3 Some College or AA degree
  5. e Ed4 College Graduate or above
  6. f MA Mexican American
  7. g OH Other Hispanic
  8. h NHB Non-Hispanic Black