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Table 4 Standardized path coefficients depicting the relationship between 5 chemicals, cognitive functioning and covariates for participants 60–69 and 70–84 years old, NHANES 1999-2002

From: A path analysis of multiple neurotoxic chemicals and cognitive functioning in older US adults (NHANES 1999–2002)

Path Path coefficient (95% CI) p-value   
Lipid-adjusted Non-lipid-adjusted Lipid-adjusted Non-lipid-adjusted
Age 60-69
PCB 74 → DSC 0.01 (−0.21, 0.23) 0.001 (−0.23, 0.23) 0.92 0.99
PCB 118 → DSC −0.10 (−0.23, 0.25) 0.02 (−0.23, 0.27) 0.93 0.89
PCB 146 → DSC −0.20 (−0.43, 0.02) −0.21 (−0.44, 0.03) 0.08 0.08
PCB 153 → DSC 0.28 (0.03, 0.53) 0.28 (0.02, 0.54) 0.03 0.04
Lead → DSC −0.13 (−0.28, 0.01) −0.13 (−0.28, 0.02) 0.07 0.08
aPIR2 → DSC 0.16 (0.03, 0.30) 0.16 (0.03, 0.29) 0.02 0.02
bPIR3 → DSC 0.33 (0.15, 0.50) 0.33 (0.15, 0.50) <0.001 <0.001
cED2 → DSC 0.25 (0.08, 0.42) 0.25 (0.08, 0.42) 0.004 0.003
dED3 → DSC 0.28 (0.17, 0.39) 0.28 (0.17, 0.39) <0.001 <0.001
eED4 → DSC 0.29 (0.18, 0.40) 0.29 (0.18, 0.41) <0.001 <0.001
fMA → DSC −0.12 (−0.20, −0.04) −0.12 (−0.20, −0.05) 0.003 0.002
gOH → DSC −0.12 (−0.26, 0.02) −0.12 (−0.26, −0.02) 0.09 0.09
hNHB → DSC −0.18 (−0.25, −0.10) −0.18 (−0.25, −0.10) <0.001 <0.001
Age → DSC −0.13 (−0.24, −0.01) −0.13 (−0.24, −0.01) 0.03 0.03
Sex → DSC 0.14 (0.05, 0.24) 0.14 (0.04, 0.23) 0.004 0.005
Smoke → DSC 0.04 (−0.11, 0.19) 0.04 (−0.11, 0.19) 0.58 0.60
Age 70–84 (N = 248)
PCB 74 → DSC −0.02 (−0.21, 0.18) −0.02 (−0.22, 0.18) 0.88 0.88
PCB 118 → DSC −0.13 (−0.29, 0.03) −0.13 (−0.31, 0.04) 0.12 0.13
PCB 146 → DSC −0.10 (−0.41, 0.21) −0.10 (−0.44, 0.23) 0.53 0.55
PCB 153 → DSC 0.12 (−0.14, 0.38) 0.13 (−0.16, 0.42) 0.37 0.40
Lead → DSC −0.08 (−0.20, 0.04) −0.08 (−0.20, 0.04) 0.19 0.17
PIR2 → DSC 0.19 (0.03, 0.35) 0.19 (0.02, 0.35) 0.02 0.03
PIR3 → DSC 0.26 (0.11, 0.42) 0.26 (0.10, 0.41) 0.001 0.001
ED2 → DSC 0.25 (0.12, 0.39) 0.25 (0.12, 0.39) <0.001 <0.001
ED3 → DSC 0.18 (0.04, 0.32) 0.18 (0.03, 0.32) 0.01 0.02
ED4 → DSC 0.30 (0.18, 0.42) 0.31 (0.19, 0.42) <0.001 <0.001
MA → DSC −0.11 (−0.18, −0.05) −0.11 (−0.17, −0.05) <0.001 <0.001
OH → DSC −0.20 (−0.32, −0.09) −0.20 (−0.31, −0.09) <0.001 <0.001
NHB → DSC −0.17 (−0.27, −0.07) −0.18 (−0.27, −0.08) <0.001 <0.001
Age → DSC −0.22 (−0.30, −0.10) −0.20 (−0.30, −0.10) <0.001 <0.001
Sex → DSC 0.10 (−0.04, 0.24) 0.11 (−0.04, 0.25) 0.15 0.15
Smoke → DSC −0.06 (−0.18, 0.07) −0.06 (−0.18, 0.07) 0.35 0.37
  1. a PIR2 2nd Tertile Poverty Index Ratio
  2. b PIR2 3 nd Tertile Poverty Index Ratio
  3. c Ed2 High School Grad/GED
  4. d Ed3 Some College or AA degree
  5. e Ed4 College Graduate or above
  6. f MA Mexican American
  7. g OH Other Hispanic
  8. h NHB Non-Hispanic Black