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Table 2 Independent and joint effects of parental occupational asthmagen exposure and parental asthma diagnosisa

From: Parental exposures to occupational asthmagens and risk of autism spectrum disorder in a Danish population-based case-control study

  Control ASD   
N % N % aORbc 95% CI
Maternal Asthmagen Maternal Asthma  
No No 23,053 78.5 5339 79.6 REF .
Yes No 5768 19.6 1226 18.3 0.93 0.86–0.99
No Yes 430 1.5 120 1.8 1.24 1.00–1.54
Yes Yes 108 0.4 21 0.3 0.90 0.55–1.47
Paternal Asthmagen Paternal Asthma  
No No 24,655 77.2 5975 78.1 REF .
Yes No 6655 20.8 1515 19.8 0.97 0.90–1.03
No Yes 517 1.6 111 1.5 0.99 0.79–1.23
Yes Yes 120 0.4 46 0.6 1.68 1.17–2.40
  1. aParental asthma defined as asthma diagnosed by a specialist prior to child’s birth
  2. bMaternal model includes maternal asthmagen exposure, child’s year of birth, child’s sex, maternal age at birth, paternal age of birth, total income of parents, parity, highest parental education, history of parental psychiatric diagnosis prior to child’s date of birth, urbanicity of birth place, maternal immigrant status, maternal smoking, maternal asthma diagnosis by a specialist prior to child’s date of birth, and interaction term between maternal asthmagen exposure and maternal asthma diagnosis by a specialist prior to the child’s date of birth (6706 cases and 29,359 controls)
  3. cPaternal model includes paternal asthmagen exposure, child’s year of birth, child’s sex, maternal age at birth, paternal age of birth, total income of parents, parity, highest parental education, history of parental psychiatric diagnosis prior to child’s date of birth, urbanicity of birth place, paternal immigrant status, maternal smoking, paternal asthma diagnosis by a specialist prior to child’s date of birth, and interaction term between paternal asthmagen exposure and paternal asthma diagnosis by a specialist prior to the child’s date of birth (7647 cases and 31,947 controls)