Table 4 Associations of arsenic exposure and LINE-1 methylation levels with BP through multivariate regression analyses

Water As

0.742 (0.189,1.294)

<0.01

0.608 (0.053,1.163)

<0.05

0.513 (−0.159,1.184)

0.133

0.509 (−0.166,1.184)

0.138

1.009 (0.078,1.941)

<0.05

0.614 (−0.324,1.551)

0.197

LINE-1

−1.084 (−1.787,−0.382)

<0.01

−0.944 (−1.652,−0.235)

<0.01

−0.138 (−1.123,0.846)

0.781

−0.097 (−1.079,0.884)

0.844

−1.786 (−2.808,−0.765)

<0.01

−1.591 (−2.652,−0.529)

<0.01

Hair As

1.324 (0.315,2.333)

<0.05

1.133 (0.129, 2.138)

<0.05

0.926 (−0.255,2.107)

0.123

0.919 (−0.268,2.107)

0.128

1.870 (0.097,3.643)

<0.05

1.301 (−0.444,3.046)

0.142

LINE-1

−0.976 (−1.679,−0.272)

<0.01

−0.097 (−1.078,0.884)

0.845

−1.625 (−2.664,−0.586)

<0.01

Nail As

1.972 (0.810,3.134)

<0.01

1.642 (0.458, 2.825)

<0.01

1.847 (0.357,3.338)

<0.05

1.850 (0.341,3.358)

<0.05

2.068 (0.240,3.897)

<0.05

1.209 (−0.656,3.074)

0.202

LINE-1

−0.854 (−1.567,−0.141)

<0.05

0.012 (−0.962,0.985)

0.981

−1.567 (−2.640,0.493)

<0.01

Water As

1.098 (0.257,1.939)

<0.05

0.888 (0.044,1.732)

<0.05

0.481 (−0.472,1.433)

0.320

0.470 (−0.487,1.428)

0.333

1.678 (0.213,3.143)

<0.05

1.140 (−0.350,2.630)

0.132

LINE-1

−1.687 (−2.755,−0.619)

<0.01

−1.481 (−2.559,− 0.403)

<0.01

−0.308 (−1.696,1.080)

0.661

−0.270 (−1.661,1.120)

0.701

−2.527 (−4.155,−0.899)

<0.01

−2.163 (−3.850,−0.476)

<0.05

Hair As

1.904 (0.367,3.441)

<0.05

1.603 (0.074, 3.133)

<0.05

1.257 (−0.410,2.925)

0.138

1.241 (−0.435,2.916)

0.145

2.562 (−0.248,5.371)

0.074

1.753 (−1.037,4.543)

0.216

LINE-1

−1.533 (−2.603,−0.426)

<0.01

−0.252 (−1.636,1.132)

0.719

−2.309 (−3.970,−0.649)

<0.01

Nail As

2.930 (1.161,4.700)

<0.01

2.408 (0.608, 4.209)

<0.01

2.368 (0.257,4.480)

<0.05

2.345 (0.209,4.482)

<0.05

3.294 (0.412,6.176)

<0.05

2.119 (−0.849, 5.086)

0.160

LINE-1

−1.349 (−2.433, 0.265)

<0.05

−0.118 (−1.496,1.261)

0.866

−2.142 (−3.850,−0.434)

<0.05