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Table 2 Associations between exposure and relative mtDNA copy number, D-loop and MT-TF methylation in adjusted modelsa

From: Occupational exposure to particles and mitochondrial DNA - relevance for blood pressure

 

mtDNA copy number

D-loop methylation

MT-TF methylation

N

Beta (95% CI)

p

N

Beta (95% CI)

p

N

Beta (95% CI)

p

Occupational group

 Welders vs. controlsb

228

0.11 (0.037, 0.18)

0.0032

211

−1.4 (−2.3, −0.5)

0.0021

220

−1.5 (−2.5, −0.48)

0.0038

Exposure level

 Respirable dustc

101

0.017 (−0.018, 0.052)

0.33

92

0.012 (−0.47, 0.50)

0.96

97

0.097 (−0.32, 0.51)

0.64

 Respirable dust (<=0.7 mg/m3)c, d

57

−0.031 (−0.47, 0.41)

0.89

54

−0.42 (−4.76, 3.9)

0.85

56

2.9 (−2.2, 8.1)

0.26

 Respirable dust (>0.7 mg/m3)c, d

41

0.037 (−0.00075, 0.075)

0.054

38

−0.043 (−0.85, 0.76)

0.92

41

0.17 (−0.29, 0.63)

0.46

 Working yearse

100

−0.0027 (−0.010, 0.0049)

0.49

93

0.061 (−0.053, 0.16)

0.29

99

−0.013 (−0.10, 0.076)

0.77

  1. aThe adjusted model included age, BMI, previous smoking years, smokeless tobacco “snus” status and current residence as adjustments
  2. bEffect estimates presented are β-values for occupation (welders compared with control) derived from general linear models
  3. cEffect estimates presented are β-values for personal respirable dust (only welders included) derived from general linear models
  4. dThe cut-off was based on median value of welders with measured and estimated respirable dust
  5. eEffect estimates presented are β-values for years working as welder (only welders included) derived from general linear models