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Animal Data
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Rodríguez et al., 2010 [46]
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Neonatal exposure of mice from D1 to D7 to BPA 0.05 or 20 mg/kg/day
| ⇘ percentage of primordial follicles ⇗ percentages of growing follicles at 20 mg/kg/day dose by increased recruitment, ⇗ proliferation of granulosa cells at every follicular stage |
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Zhang et al., 2012 [45]
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Exposure of pregnant mice at 0.02, 0.04 or 0.08 mg/kg/day of orally administered BPA from Day 12.5 post coïtum.
| ⇘ number of primordial follicles at D3 by defaults in assembly associated with. a delay in meiosis I progression ⇘ mRNA expression of specific meiotic genes |
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Li et al., 2014 [47]
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Intraperitoneal injection of 10, 40 or 160 mg/kg of BPA in prepubertal rats for 1 week
| ⇘ ovary weight, ⇘ number of primordial follicles at the highest dose, dose –dependant ⇘ in numbers of total, primary/preantral and antral follicles, ⇗ number of atretic follicles |
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Berger et al., 2015 [44]
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Exposure of pregnant mice to BPA: 0.5, 20 or 50 μg/kg/day, histological analysis of ovaries and gene expression analysis at postnatal D4 and D21 from F1 to F3
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Alteration in the number of follicles for F1, but not for F2 and F3. Alterations in ovarian gene expression at D21 with a transgenerational effect
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