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Table 3 Model estimates for the association between maternal total urinary BPA (log10 ng/mL) concentration and infant salivary cortisol concentration (natural log μg/dL): n = 132

From: Prenatal bisphenol a exposure and dysregulation of infant hypothalamic-pituitary-adrenal axis function: findings from the APrON cohort study

  Model 1: BPA Model 2: BPA with sex Model 3: BPA with sex and creatinine
Fixed Effects β Coefficient (95% CI) % change (95% CI) β Coefficient (95% CI) % change (95% CI) β Coefficient (95% CI) % change (95% CI)
INTERCEPT (baseline cortisol) .31 (.12, .49) GM = .37 μg/dL at baseline .31 (.12, .50) GM = .38 μg/dL at baseline for females .31 (.12, .50) GM = .38 μg/dL at baseline for females
Time of day for urine collection (hours) .001 (−.006, .008)   .002 (−.005, .009)   .002 (−.005, .009)  
Gestational age at urine collection (weeks) −.004 (−.01, .003)   −.005 (−.01, .003)   −.005 (−.01, .003)  
Gestational age at birth (weeks) −.005 (−.02, .01)   −.006 (−.02, .01)   −.005 (−.02, .01)  
Creatinine (mmol/L)      .0001 (−.005, .005)  
Infant Sex    −.02 (−.07, .03)   −.02 (−.07, .03)  
BPA (log10 ng/mL) .002 (−.08, .08) .2% (−.8, .8) increase per 10-fold increase in BPA at baseline .13 (.01, .26) 14% (.7, 30) increase per 10-fold increase in BPA at baseline for females .13 (−.01, .28) 14% (−1, 32) increase per 10-fold increase in BPA at baseline for females
BPA X sex    −.22 (−.39, −.05) −20% (−32, −5) difference between males and females; net effect is 8.1% decrease per 10-fold increase in BPA at baseline for males −.22 (−.39, −.05) −20% (−32, −5) difference between males and females; net effect is a 9% decrease per 10-fold increase in BPA at baseline for males
TIME 2 (hours) −.33 (−.47, −.18)   −.33 (−.48, −.18)   −.33 (−.48, −.18)  
TIME (hours) .31 (.19, .44) 37% (21, 55) increase per hour .32 (.19, .46) 38% (21, 58) increase per hour for females .32 (.19, .45) 38% (21, 57) per hour for females
Gestational age at birth (weeks) −.02 (−.04, .01)   −.02 (−.04, .01)   −.02 (−.04, .01)  
Creatinine (mmol/L)      .003 (−.005, .01)  
Infant Sex    −.03 (−.11, .05) −3% (−10, 5) difference between males and females; net effect is 34% increase per hour in males −.02 (−.11, .06) −3% (−10, 5) difference between males and females; net effect is 34% increase per hour in males
BPA (log10 ng/mL) .02 (−.11, .15) 2% (−10, 17) per hour per 10-fold increase in BPA −.15 (−.35, .05) −14% (−30, 5) decrease per hour for females per 10-fold increase in BPA −.20 (−.43, .03) −18% (−35, 3) decrease per hour for females per 10-fold increase in BPA
BPA X sex    .30 (.04, .56) 35% (4, 75) difference between males and females; net effect is a 17% per hour increase in males per 10-fold increase in BPA .33 (.06, .60) 39% (6, 82) difference between males and females; net effect is a 15% per hour increase in males per 10-fold increase in BPA
  1. Note. Time was centered at baseline; sex was centered at female; all other variables were centered at the grand mean. Because total BPA was log10 transformed, the interpretation of the estimates are per 10-fold change in BPA