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Table 5 Pathways modulated by short-term PM2.5 exposure for girls and boys resulting from GSEA

From: Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort

Sex

Cluster label

Source: pathway

# genes

Direction of regulation

Girls

Olfactory signaling

Reactome: olfactory signaling pathway

95

DOWN

Rho pathway

BioCarta: Rho pathway

28

DOWN

Ribosome related pathways

  

UP

 

Reactome: nonsense mediated decay enhanced by the exon junction complex

104

KEGG: ribosome

85

Reactome: 3′ UTR mediated translational regulation

102

Boys

ATM pathway

PID: ATM pathway

18

UP

BARD1 pathway

PID: BARD1 pathway

29

UP

Cell Cycle

  

UP

 

Reactome: DNA replication

176

Reactome: G2/M checkpoints

37

Reactome: cell cycle mitotic

290

ETC-TCA cycle

  

UP

 

Reactome: TCA cycle and respiratory electron transport

113

Reactome: respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins

79

M-calpain pathway

BioCarta: M-calpain pathway

21

UP

 

Metabolism of mRNA and RNA

  

UP

 

Reactome: metabolism of RNA

249

Reactome: metabolism of mRNA

204

Myc pathway

PID: Myc activ pathway

76

UP

Olfactory signaling

  

DOWN

 

KEGG: olfactory transduction

124

Reactome: olfactory signaling pathway

95

mRNA processing

  

UP

 

Reactome: processing of capped intron containing pre mRNA

133

UP

Reactome: mRNA processing

147

 

Response to elevated platelet cytosolic CA2+

Reactome: response to elevated platelet cytosolic CA2+

66

UP

Ribosome related pathways

  

UP

 

Reactome: translation

141

Reactome: SRP dependent cotranslational protein targeting to membrane

105

Reactome: 3′ UTR mediated translational regulation

102

RhoA pathway

PID: RhoA pathway

37

UP

Splicesome

KEGG: spliceosome

123

UP

  1. For clusters containing more than 3 pathways, only the top 3 significant pathways are given
  2. # genes: number of genes within a pathway. Rho Ras Homolog gene family, TCA tricarboxylic acid, ETC electron transport chain, ATM Ataxia Telangiectasia Mutated, BARD1 BRCA1 associated RING domain 1. Myc v-myc avian myelocytomatosis viral oncogene homolog, PID Pathway Interaction Database, KEGG Kyoto Encyclopedia of Genes and Genomes