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Table 6 Hazard ratios and 95% CI for the associations of incident COPD, adult-onset asthma, and lung cancer with an IQR increase in each pollutant by age and sex in Toronto, Canada

From: Long-term exposure to ambient ultrafine particles and respiratory disease incidence in in Toronto, Canada: a cohort study

Covariates

No. of cases

UFPs

PM2.5

NO2

HR

95% CI

HR

95% CI

HR

95% CI

COPD

 Age

<60

28,854

1.07

1.04

1.11

1.05

1.02

1.08

1.14

1.11

1.17

60–74

32,092

1.00

0.97

1.03

1.06

1.03

1.08

1.08

1.06

1.11

> = 75

13,597

1.01

0.98

1.04

1.08

1.05

1.11

1.02

0.99

1.05

 Sex

Men

39,111

1.04

1.01

1.06

1.07

1.05

1.10

1.10

1.07

1.14

Women

35,432

1.06

1.03

1.08

1.06

1.04

1.09

1.10

1.05

1.14

Asthma

 Age

<60

58,934

1.01

1.00

1.02

1.01

0.99

1.03

1.04

1.02

1.06

60–74

21,754

1.00

0.98

1.02

1.04

1.02

1.07

1.03

1.01

1.05

 Sex

> = 75

6453

1.01

0.97

1.05

1.02

0.98

1.06

1.00

0.97

1.04

Men

35,019

1.02

1.00

1.04

1.02

1.00

1.03

1.03

1.01

1.04

Women

52,122

1.00

0.98

1.01

1.03

1.01

1.04

1.03

1.01

1.05

Lung Cancer

 Age

<60

5891

1.00

0.96

1.04

1.04

1.01

1.08

1.04

1.01

1.08

60–74

5969

1.00

0.97

1.03

1.05

1.03

1.08

1.07

1.04

1.10

 Sex

> = 75

1048

1.01

0.93

1.09

1.04

0.98

1.10

1.02

0.93

1.10

Men

7085

1.00

0.96

1.04

1.06

1.02

1.09

1.09

1.05

1.12

Women

5823

0.98

0.93

1.03

1.06

1.03

1.10

1.06

1.02

1.10

  1. All models are stratified by age and sex, include a frailty term for neighborhoods, and are adjusted for neighborhood-level covariates