Table 7 Sensitivity analyses for the associations of respiratory disease incidence with PM2.5
Sensitivity analysis | COPD | Asthma | Lung cancer a | ||||||
|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | HR | 95% CI | HR | 95% CI | ||||
Results from the Main Analyses (Table 4) | 1.06 | 1.04 | 1.08 | 1.02 | 1.00 | 1.04 | 1.05 | 1.03 | 1.08 |
Two different time windows of exposure | |||||||||
1 year before event | 1.05 | 1.04 | 1.07 | 1.01 | 1.00 | 1.03 | NA | NA | NA |
2 year before event | 1.06 | 1.04 | 1.07 | 1.02 | 1.00 | 1.03 | NA | NA | NA |
Two different lags in the exposure | |||||||||
0-year lag b | NA | NA | NA | NA | NA | NA | 1.04 | 1.01 | 1.08 |
2-year lag c | NA | NA | NA | NA | NA | NA | 1.05 | 1.02 | 1.08 |
Restricted to subjects who lived at their baseline addresses for ≥5 years prior to cohort entry | 1.06 | 1.04 | 1.08 | 1.02 | 1.00 | 1.03 | 1.05 | 1.03 | 1.08 |
Adjusted for a linear term for time | 1.06 | 1.04 | 1.08 | 1.02 | 1.00 | 1.04 | 1.05 | 1.03 | 1.08 |
Adjusted for the distance to roadways | 1.06 | 1.04 | 1.08 | 1.02 | 1.00 | 1.03 | 1.05 | 1.03 | 1.08 |
Indirect adjustment (with HRs directly calculated from the CCHS cohort) | |||||||||
+ Smoking only | 1.04 | 0.99 | 1.08 | 1.02 | 1.00 | 1.04 | 1.03 | 0.95 | 1.11 |
+ Smoking and BMI | 1.04 | 0.97 | 1.09 | 1.03 | 1.00 | 1.05 | 1.01 | 0.93 | 1.10 |