Table 1 Basic information, primer and probe sequences of selected SNPs
No. | Gene | rs No. | location | allele | MAF (CHB) | Primers for PCR | Probes for detecting variations | P HWE |
|---|---|---|---|---|---|---|---|---|
1 | CASP1 | rs1977989 | 11:105,026,117 | A/G | 0.232 | F:TGAATATCATGTGGGCGCTC R:TTTCTACCTCTTCCCAGGAC | TA:GGATTTTAGAGCATTTCAAAATTCA TG:TTTGGATTTTAGAGCATTTCAAAATTCG TR:AATTTTTGGATTAAGGATTCTCAGC | 0.325 |
2 | CASP3 | rs1049216 | 4:184,628,935 | C/T | 0.2 | F:GTGCAGTCATTATGAGAGGC R:TTTGAGCCTTTGACCATGCC | TC:TTTTTTTTTGAAAAAGTTAAACATTGAAGTAAC TT:TTTTTTTTTTTTGAAAAAGTTAAACATTGAAGTAAT TR:GAATTTTTATGATATTCCCCCCACTTTTTTT | 0.279 |
3 | CASP3 | rs6948 | 4:184,627,976 | A/C | 0.16 | F:TGTTCTAAAGGTGGTGAGGC R:TGAGACTTGGTGCAGTGACG | TA:TTTTTTTTTTTTTCCAGCCGGAGGCCAGAGCTGAGCA TC:TTTTTTTTTTTTTTTTCCAGCCGGAGGCCAGAGCTGAGCC TR:CTCAGCCCGGGAGGCAGGCTCCAGGTTTTTTTTT | 0.264 |
4 | CASP4 | rs630003 | 11:104,970,269 | G/C | 0.25 | F:CTTCTGCCTGGTTGATTTGG R:GCTGAGATGGATGAACTGAC | TC:TTTTGATACTTGTGTTTGAATCATGAAGC TG:TTTTTTTGATACTTGTGTTTGAATCATGAAGG TR:TCTCACGCTGTGTTTCTCAGCTCCATTT | 0.911 |
5 | CASP5 | rs507879 | 11:105,007,200 | A/G | 0.329 | F:GTTAAGATGTTGGAATACCTG R:GATCTTTTGGTCCATATTGAG | TA:TTTTTTTTGAGGAAAAGAAAAAATATTATGATA TG:TTTTTTTTTTTGAGGAAAAGAAAAAATATTATGATG TR:CCAAAATTGAAGACAAGGCCCTGATTTTTTT | 0.522 |
6 | CASP5 | rs523104 | 11:104,998,981 | G/C | 0.211 | F:GCCTATCTTGATTTCATAGAA R:AGAAAAACATGGGGAACTCTG | TC:TTTTTTTTTTTTTCTCAGATGACTGTGAAGAGATGAC TG:TTTTTTTTTTTTTTTTCTCAGATGACTGTGAAGAGATGAG TR:TGCCAAGGATGCTGGAGAGTCTCTGTTTTTTTTT | 0.623 |
7 | CASP6 | rs1042891 | 4:109,688,930 | C/T | 0.483 | F:AATCCCAGCTACTTGGAAGG R:TAAGGCAGTTCTCTGCTAGG | TC:TCGTTAGGGTGAAGCATTATGGTCC TT:TTTTCGTTAGGGTGAAGCATTATGGTCT TR:AATGATTCAAATGTTTTAAAGTTTA | 0.581 |
8 | CASP8 | rs1045494 | 2:201,287,058 | T/C | 0.183 | F:CTGGCCGATGGTACTATTTAG R:TAAGCCCTCTATATTCATAGC | TC:TTTTTTTTTTTTTTTTAATAACACTGTCTCCTTTCTCTTAC TT:TTTTTTTTTTTTTTTTTTTAATAACACTGTCTCCTTTCTCTTAT TR:GCTTAAGGCTTTGGGAATGTTTTTAGCTGGTTTTTTT | 0.522 |
9 | CASP8 | rs3769823 | 2:201,258,272 | C/T | 0.366 | F: ATATTGTGGTTTCCTGTTGAAG R: TAGTCAACTCAACAGGAAGTG | TC:AAGGCTCCCAGGAAGAAGTTTCTTC TT:TTTAAGGCTCCCAGGAAGAAGTTTCTTT TR:TACTTTCAATAACCACCCTGGCTCT | <0.001 |
10 | CASP9 | rs1052576 | 1:15,506,048 | G/A | 0.366 | F:TGCTTCTGGCTCACCTGCAGC R:TTGGACACAAGAAGGGACATG | TA:TTTTTGCTGGCTTTGCTGGAGCTGGCGCA TG:TTTTTTTTGCTGGCTTTGCTGGAGCTGGCGCG TR:GCAGGACCACGGTGCTCTGGACTGCTTT | 0.802 |
11 | CASP9 | rs4645978 | 1:15,525,539 | A/G | 0.392 | F:GAAAAGTGGCTAGCACGATG R:CTGTTCCAAACTCGAGTGTC | TA:GTGTGGGAGGTGTTAGGGTGGGAGA TG:TTTGTGTGGGAGGTGTTAGGGTGGGAGG TR:GAGGGAAGAGGGAATGGAAGACTGT | 0.324 |
12 | CASP10 | rs13006529 | 2:201,217,736 | A/T | 0.2 | F:CTGCTGTCAACGATGATGTG R:CTAGAATGACAGGTGGAGAC | TA:CCTGTGCCCCTGGATGCACTTTCAA TT:TTTCCTGTGCCCCTGGATGCACTTTCAT TR:TATAGCAGAGAGTTTTTGTTGGTTC | 0.452 |
13 | CASP10 | rs3900115 | 2:201,185,954 | A/G | 0.22 | F:GCTGGCCATGAAATCTCAAG R:AAAGGGTCTTCCTCACTCAG | TA:TTTTGCTGGAGAAGTCCAGCTCAGCCTCA TG:TTTTTTTGCTGGAGAAGTCCAGCTCAGCCTCG TR:GATGTTTTTGAACATCTCTTGGCAGTTT | 0.341 |
14 | CASP14 | rs3181312 | 19:15,057,642 | A/C | 0.466 | F:CCTCAGCTTCTCATATCTGC R:TTAACTCCTGGCCTCAAGTG | TA:TTTTAGTGGCTCACACCTGTATTCCCGAA TC:TTTTTTTAGTGGCTCACACCTGTATTCCCGAC TR:TTTGAGAGTCTGAAGCGGGAGGATCTTT | 0.272 |
15 | CASP14 | rs3181309 | 19:15,056,984 | T/C | 0.279 | F:ATTCCCTGTTGTCACCTTGC R:AGCTCCTACCTTGGAGATAG | TC:CTCTTTTCCACAACCTGCTAAATCC TT:TTTCTCTTTTCCACAACCTGCTAAATCT TR:TGATCCATCTGAAAACTTTTCTAAT | 0.136 |