Table 4 Crossover analysis of interaction between SNPs and working time on NIHL risk
SNP | Genotype | Working time(h/week) | Controls, n (%) | Cases, n (%) | P | OR(95%CI)a |
|---|---|---|---|---|---|---|
rs1049216 | CT + TT | ≤ 48 | 59(21.9) | 43(16.0) | 1.0 | |
CC | ≤ 48 | 95(35.3) | 91(33.8) | 0.046 | 1.870(1.012–3.457) | |
CT + TT | > 48 | 37(13.8) | 31(11.5) | 0.083 | 2.263(0.900–5.689) | |
CC | > 48 | 78(29.0) | 104(38.7) | 0.001b | 3.989(1.787–8.907) | |
rs6948 | AC + CC | ≤ 48 | 56(20.8) | 42(15.6) | 1.0 | |
AA | ≤ 48 | 98(36.4) | 92(34.2) | 0.087 | 1.716(0.925–3.184) | |
AC + CC | > 48 | 36(13.4) | 29(10.8) | 0.123 | 2.076(0.821–5.251) | |
AA | > 48 | 79(29.4) | 106(39.4) | 0.001b | 3.817(1.710–8.522) | |
Risk genotype | < 2 | ≤ 48 | 60(22.3) | 43(16.0) | 1.0 | |
2 | ≤ 48 | 94(34.9) | 91(33.8) | 0.045 | 1.875(1.014–3.467) | |
< 2 | > 48 | 37(13.8) | 31(11.5) | 0.082 | 2.267(0.902–5.699) | |
2 | > 48 | 78(29.0) | 104(38.7) | 0.001b | 3.995(1.790-8.919) |