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Table 2 Cox regression analysis: Hazard Ratio (HR) for the development of arsenic induced skin lesions by presence or absence of genomic deletions in different chromosomal locations in male subjects

From: Association between genome-wide copy number variation and arsenic-induced skin lesions: a prospective study

CNV genomic coordinates (GRCh37/hg19) Cytoband Length (bps) Nearest Gene Distance to Nearest Gene (bps) HR (gene) Male subjecta 95% CI (gene) p-value (gene) Bonferroni p-value (gene) Male subjects interaction p-value Nearest reported CNV in DGV database Distance to Nearest reported CNV
chr9:40,768,295-40,779,600 9p13.1 11,306 ZNF658 (−) 0 2.42 1.62 3.62 1.76E-05 0.020 0.048 chr9:40,773,931..40940341 0
chr9:40,779,600-40,794,798 9p13.1 15,199 ZNF658 (−) 0 2.41 1.60 3.63 2.77E-05 0.031 0.054 chr9:40,781,674..40784428 0
chr9:40,794,798-40,812,799 9p13.1 18,002 ZNF658 (−) 0 2.55 1.71 3.79 4.01E-06 0.005 0.035 chr9:40,773,931..40940341 0
chr9:40,824,400-40,839,148 9p13.1 14,749 ZNF658 (−) 0 2.16 1.50 3.12 3.95E-05 0.045 0.180 chr9:40,832,700..41365793 0
chr15:29,214,310-29,222,222 15q13.1 7913 APBA2 (+) 0 2.59 1.64 4.09 4.53E-05 0.051 0.006 chr15:29,212,947..29288420 0
chr15:29,222,222-29,231,330 15q13.1 9109 APBA2 (+) 0 3.08 1.83 5.19 2.29E-05 0.026 0.001 chr15:29,212,947..29288420 0
  1. aHazard Ratio if genomic deletion is present; Cox regression model includes: genomic segment, age, gender, UACR and interaction term “genomic segment x gender”
  2. Top genomic segments are sorted by chromosome