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Table 3 Cox regression analysis: Hazard Ratio (HR) for the development of arsenic induced skin lesions by presence or absence of genomic deletions in different chromosomal locations in female subjects

From: Association between genome-wide copy number variation and arsenic-induced skin lesions: a prospective study

CNV genomic coordinates (GRCh37/hg19)

Cytoband

Length (bps)

Gene

Distance to Nearest Gene (bps)

HR (gene) Female subjecta

95% CI (gene)

p-value (gene)

Bonferroni p-value (gene) Female subjects

interaction p-value

Nearest reported CNV in DGV database

Distance to Nearest reported CNV

chr8:14,696,759-14,702,931

8p22

6173

SGCZ (−)

0

2.43

1.60

3.69

3.03E-05

0.034

0.057

chr8:14,697,130..14719288

0

chr8:14,702,931-14,710,309

8p22

7379

SGCZ (−)

0

2.46

1.63

3.72

1.91E-05

0.022

0.040

chr8:14,697,130..14719288

0

  1. aHazard Ratio if genomic deletion is present; Cox regression model includes: genomic segment, age, gender, UACR and interaction term “genomic segment x gender”
  2. Top genomic segments are sorted by chromosome