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Table 4 Cox regression analysis: Hazard Ratio (HR) for the development of arsenic induced skin lesions by presence or absence of genomic deletions in different chromosomal locations in subjects with higher arsenic exposure (urinary arsenic creatinine ratio > = median value of 192 μg/g of creatinine)

From: Association between genome-wide copy number variation and arsenic-induced skin lesions: a prospective study

CNV genomic coordinates (GRCh37/hg19) cytoband length (bps) Nearest Gene Distance to Nearest Gene (bps)b HR (gene) high UACRa 95% CI (gene) p-value (gene) Bonferroni p-value (gene) high UACR interaction p-value high UACR Nearest reported CNV in DGV database Distance to Nearest reported CNV (bps)c
chr2:104,543,558-104,558,092 2q12.1 14,535 RP11-76I14.1 (+) 0 2.05 1.52 2.76 2.41E-06 0.003 0.077 chr2:104,593,605..104760102 35,513
chr2:104,558,092-104,568,449 2q12.1 10,358 RP11-76I14.1 (+) 0 2.05 1.52 2.76 2.21E-06 0.003 0.075 chr2:104,593,605..104760102 25,156
chr2:104,573,423-104,581,271 2q12.1 7849 RP11-76I14.1 (+) 0 1.98 1.47 2.67 5.86E-06 0.007 0.103 chr2:104,593,605..104760102 12,334
chr3:102,717,330-102,770,447 3q12.3 53,118 RNU1-43P (+) 108,357 2.39 1.60 3.57 2.11E-05 0.024 0.348 chr3:102,743,602..102752706 0
chr5:117,349,895-117,357,592 5q23.1 7698 CTD-3179P9.1 (+) 0 2.36 1.57 3.56 3.80E-05 0.043 0.013 chr5:117,280,136..117451273 0
chr5:117,357,592-117,368,561 5q23.1 10,970 CTD-3179P9.1 (+) 0 2.35 1.56 3.53 4.37E-05 0.050 0.016 chr5:117,280,136..117451273 0
chr5:164,917,182-164,925,967 5q34 8786 CTC-535 M15.2 (+) 0 2.57 1.69 3.89 9.35E-06 0.011 0.224 chr5:164,849,860..164874815 42,367
chr5:164,925,967-164,939,621 5q34 13,655 CTC-535 M15.2 (+) 0 2.51 1.67 3.78 1.03E-05 0.012 0.214 chr5:164,849,860..164874815 51,152
chr5:164,939,621-164,956,122 5q34 16,502 CTC-535 M15.2 (+) 0 2.49 1.65 3.75 1.23E-05 0.014 0.223 chr5:164,849,860..164874815 64,806
chr5:164,956,122-164,973,175 5q34 17,054 CTC-535 M15.2 (+) 0 2.50 1.65 3.78 1.65E-05 0.019 0.287 chr5:164,849,860..164874815 81,307
  1. aHazard Ratio if genomic deletion is present; Cox regression model includes: genomic segment, age, gender, UACR and interaction term “genomic segment x UACR”. Rows representing linc RNA regions are shown in bold font
  2. bgenomic segments with “Distance to nearest gene” >0 indicates that the segment doesn’t cover the gene, but it is close to that gene. cgenomic segments with “Distance to nearest reported CNV” = 0 indicates that the identified CNV overlaps with known CNV repoted in the DGV
  3. Top genomic segments are sorted by chromosome