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Fig. 3 | Environmental Health

Fig. 3

From: Genetic and epigenetic susceptibility of airway inflammation to PM2.5 in school children: new insights from quantile regression

Fig. 3

Estimated joint effects of NOS2 H1 haplotype, iNOS methylation and 7-day average PM2.5 exposure across the selected quantiles of FeNO distribution and its mean by asthma status. In each panel, data are presented by number of H1 haplotype copy. The X-axis shows the combination of levels in methylation (first number in the bracket) and short-term PM2.5 exposure (second number in the bracket). Selected methylation levels are population average, 5% and 10% lower than averages, which are indexed by 0,-5 and −10, respectively. Selected PM2.5 exposure levels are population average, 5 μg/m3 and 10 μg/m3 higher PM2.5 exposure levels than average, which are indexed by 0, 5 and 10, respectively. The estimated joint effects when methylation levels are at population average, 5% and 10% lower than average are represented by black, red and green lines, respectively. Note: Y-axis limit for asthma group is wider than that for non-asthma group. a Asthma Group b Non-Asthma Group

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