Skip to main content

Table 4 Association between head and neck cancer sites and exposure to chlorinated solvents

From: Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in France

Exposure

 

Oral cavity

Oropharynx

Hypopharynx

Oral cavity/pharynx NOS

Larynx

 

n = 328

n = 502

n = 338

n = 114

n = 423

Co

Ca

ORa

Ca

ORa

Ca

ORa

Ca

ORa

Ca

ORa

[95%CI]

 

[95%CI]

 

[95%CI]

 

[95%CI]

 

[95%CI]

PCE

 Never

2581

318

1

482

1

324

1

111

1

400

1

 Ever

  

0.69

[0.32 to 1.48]

 

0.98

[0.54 to 1.78]

 

1.15

[0.58 to 2.27]

 

0.63

[0.19 to 2.14]

 

1.29

[0.73 to 2.28]

 CEI

 Low

44

4

0.55

[0.18 to 1.69]

12

1.39

[0.65 to 2.97]

8

1.47

[0.61 to 3.51]

2

0.87

[0.19 to 3.97]

10

1.29

[0.59 to 2.85]

 Medium

34

6

0.97

[0.35 to 2.67]

4

0.44

[0.14 to 1.40]

5

0.79

[0.26 to 2.36]

0

-

5

0.69

[0.24 to 1.99]

 High

11

0

-

4

1.81

[0.49 to 6.62]

1

0.72

[0.08 to 6.18]

1

1.30

[0.14 to 11.75]

8

3.86

[1.30 to 11.48]

 p for trend

  

0.40

 

0.79

 

0.79

 

0.74

 

0.04

TCE

 Never

1686

171

1

281

1

176

1

69

1

241

1

 Ever

  

1.24

[0.91 to 1.70]

 

0.99

[0.76 to 1.30]

 

1.00

[0.73 to 1.37]

 

0.79

[0.49 to 1.27]

 

0.95

[0.72 to 1.26]

 CEI

 Low

497

77

1.00

[0.70 to 1.42]

121

0.99

[0.73 to 1.34]

71

0.86

[0.60 to 1.24]

21

0.68

[0.39 to 1.19]

101

0.99

[0.72 to 1.35]

 Medium

397

69

1.20

[0.83 to 1.74]

84

0.88

[0.63 to 1.23]

74

1.08

[0.74 to 1.56]

21

0.83

[0.46 to 1.47]

65

0.78

[0.55 to 1.12]

 High

95

11

0.87

[0.43 to 1.76]

18

0.81

[0.45 to 1.76]

17

1.05

[0.57 to 1.96]

4

0.63

[0.21 to 1.89]

16

0.69

[0.38 to 1.28]

 p for trend

  

0.90

 

0.34

 

0.60

 

0.47

 

0.11

MC

 Never

2432

296

1

443

1

295

1

101

1

373

1

 Ever

  

0.80

[0.51 to 1.24]

 

0.94

[0.65 to 1.35]

 

1.02

[0.67 to 1.55]

 

0.87

[0.45 to 1.69]

 

1.01

[0.69 to 1.47]

 CEI

 Low

114

13

0.57

[0.30 to 1.08]

33

1.07

[0.67 to 1.72]

19

0.90

[0.51 to 1.59]

7

1.01

[0.43 to 2.36]

35

1.46

[0.92 to 2.32]

 Medium

100

15

0.81

[0.43 to 1.51]

21

0.73

[0.41 to 1.27]

14

0.70

[0.37 to 1.35]

5

0.74

[0.28 to 1.99]

8

0.37

[0.17 to 0.80]

 High

24

4

1.19

[0.37 to 3.85]

5

0.88

[0.30 to 2.57]

10

2.36

[0.98 to 5.85]

1

0.72

[0.09 to 5.95]

7

1.51

[0.58 to 3.94]

 p for trend

  

0.93

 

0.51

 

0.22

 

0.63

 

0.69

CF

 Never

2619

326

1

496

1

334

1

113

1

422

1

 Ever

  

0.44

[0.10 to 2.01]

 

1.05

[0.39 to 2.84]

 

1.28

[0.39 to 4.13]

 

0.73

[0.09 to 5.92]

 

0.18

[0.02 to 1.38]

 CEI

           

 Low

25

1

0.45

[0.05 to 3.91]

1

0.42

[0.05 to 3.57]

2

1.45

[0.27 to 7.83]

0

-

1

0.40

[0.05 to 3.43]

 Medium - High

26

1

0.35

[0.04 to 3.43]

5

1.16

[0.37 to 3.71]

2

0.80

[0.16 to 4.00]

1

0.95

[0.11 to 8.15]

0

-

 p for trend

  

0.47

 

0.27

 

0.26

 

0.56

 

0.01

CT

 Never

2622

327

1

495

1

333

1

112

1

419

1

 Ever

  

0.17

[0.02 to 1.31]

 

0.92

[0.37 to 2.33]

 

1.05

[0.36 to 3.03]

 

0.98

[0.21 to 4.54]

 

0.38

[0.11 to 1.33]

 CEI

 Low

24

0

-

3

0.74

[0.19 to 2.91]

2

0.65

[0.13 to 3.38]

1

0.83

[0.10 to 7.31]

1

0.25

[0.03 to 2.02]

 Medium

24

1

0.30

[0.04 to 2.42]

4

0.92

[0.27 to 3.12]

3

1.08

[0.28 to 4.20]

1

0.97

[0.12 to 8.06]

3

0.64

[0.17 to 2.43]

 High

 p for trend

  

0.18

 

0.84

 

0.98

 

0.96

 

0.40

At least one chlorinated solvent

 Never

1645

171

1

276

1

174

1

68

1

241

1

 Ever

  

1.17

[0.86 to 1.60]

 

0.99

[0.76 to 1.29]

 

1.00

[0.73 to 1.36]

 

0.79

[0.50 to 1.27]

 

0.91

[0.69 to 1.20]

 CEI

 Low

518

77

0.97

[0.69 to 1.38]

117

0.97

[0.71 to 1.31]

73

0.87

[0.61 to 1.25]

22

0.72

[0.41 to 1.26]

108

1.02

[0.75 to 1.39]

 Medium

408

64

1.05

[0.72 to 1.52]

89

0.93

[0.67 to 1.29]

64

0.93

[0.64 to 1.36]

21

0.83

[0.47 to 1.47]

53

0.61

[0.42 to 0.89]

 High

104

16

1.05

[0.57 to 1.96]

22

0.82

[0.48 to 1.39]

27

1.38

[0.81 to 2.36]

4

0.50

[0.17 to 1.96]

21

0.80

[0.46 to 1.39]

 p for trend

  

0.75

 

0.48

 

0.26

 

0.27

 

0.07

  1. Abbreviations PCE perchloroethylene, TCE trichloroethylene, MC methylene chloride, CF chloroform, CT carbon tetrachloride, OR odds ratio, CI confidence interval, CEI cumulative cxposure index, Ca cases, Co controls
  2. aOR adjusted for age at interview, residence area, alcohol consumption, smoking status, frequency and duration of smoking, exposure to asbestos
Back to article page

Environmental Health

ISSN: 1476-069X