From: Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure
Pathway | Effective/ total size | # ↓ genes | Contributing genes (#)§ | P-value |
---|---|---|---|---|
Women | ||||
 IL12-mediated signaling events | 57/67 | 33 | TBX21↓;CD247↓;MAPK14↑;CCL4↓;CCR5↓(20) | 1.8E-06 |
 role of mef2d in t-cell apoptosis | 28/31 | 25 | CD247↓;ZAP70↓;FYN↓;LAT↓;CD3E↓;CABIN1↓;PPP3CC↓;LCK↓;PLCG1↓;CAPN2↓;CD3D↓(11) | 1.2E-04 |
 T cell receptor signaling pathway | 96/104 | 52 | CD247↓;PDCD1↓;MAPK14↑;ZAP70↓;FYN↓(22) | 8.0E-04 |
 Ribosome | 128/135 | 100 | RPLP2↓;MRPL16 ↓; RPL36↓;RPL35↓;RPL18↓(27) | 8.6E-04 |
 Natural killer cell mediated cytotoxicity | 104/134 | 50 | CD247↓;HCST↓;ZAP70↓;FYN↓;LAT↓(23) | 1.0E-03 |
 Downstream signaling in naïve CD8+ T cells | 52/71 | 33 | CD247↓;IL2RB↓;EOMES↓;CD8A↓;CD3E↓;PRF1↓;TNFRSF4↓;PTPN7↓;STAT4↓;GZMB↓;BRAF↑;MAPK3↑;CD3D↓;MAPK1↑(14) | 1.4E-03 |
 Formation of a pool of free 40S subunits | 94/151 | 71 | RPLP2↓;RPL36↓;RPL35↓;RPL18↓;RPLP1↓(21) | 1.5E-03 |
 Primary immunodeficiency | 32/36 | 24 | ZAP70↓;ADA↓;RFXAP↓;DCLRE1C↓;CD8A↓;CD3E↓;CD19↓;ICOS↓;LCK↓;CD3D↓(10) | 2.0E-03 |
 TCR signaling in naïve CD8+ T cells | 54/58 | 35 | RASGRP2↓;CD247↓;ZAP70↓;FYN↓;LAT↓;CARD11↓;CD8A↓;CBL↑;RASGRP1↓;CD3E↓;PRF1↓;LCK↓;PLCG1↓;CD3D↓(14) | 2.0E-03 |
 Mitochondrial translation (elongation)* | 84/85 | 72 | MRPL38 ↓; MRPL16 ↓; MRPS9 ↓; MRPL4 ↓; MRPS26↓ (19) | 2.1E-03 |
 NF-κB signaling pathway | 86/91 | 43 | PARP1↓;TRAF2↓;ZAP70↓;CCL4↓;TRAF5↓(19) | 2.8E-03 |
 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 64/132 | 41 | CD247↓;HCST↓;ICAM4↑;ITGB7↓;CD8A↓;CD96↓;KIR2DL2↓; CD3E↓;CD19↓;KIR3DL1↓;KLRD1↓;KIR3DL2↓;ITGB1↓;ITGA4↓;CD3D↓(15) | 4.2E-03 |
 Busulfan Pathway, Pharmacodynamics | 30/36 | 16 | BNIP3 ↓; CHEK2↓;BCL2L1 ↑; MLH1 ↓; FMO5↑;LTBR↑;GSTP1↓;GGT1↑;MPG↓(9) | 4.5E-03 |
 Cell cycle | 116/124 | 63 | ZBTB17↓;ANAPC1↓;CDK4↓;MCM7↓;CHEK2↓(23) | 4.6E-03 |
 Downregulation of SMAD2/3:SMAD4 transcriptional activity | 20/21 | 10 | PARP1↓;NCOR2↓;RPS27A↓;SMAD3↓;UBB↑;PPM1A↑;NEDD4L↑(7) | 4.6E-03 |
Men | ||||
 Meiotic recombination | 53/64 | 3 | HIST1H3C↑;HIST1H2B↑;HIST2H3A↑;HIST1H2B↑;HIST3H2B↑(22) | 1.3E-12 |
 Cytokine Signaling in Immune system | 156/198 | 49 | STAT2↑;IRS2↑;CSH1↑;PELI1↑;EIF4E3↑(24) | 1.7E-04 |
 Osteoclast differentiation | 120/131 | 25 | CYBA↑;FCGR3B↑;FOSL2↑;GRB2↑;IFNAR1↑(20) | 2.0E-04 |
 Phagosome | 135/155 | 35 | ATP6V1E1↑;CD14↑;CYBA↑;CLEC4M↑;FCAR↑(21) | 3.7E-04 |
 GMCSF-mediated signaling events | 36/41 | 10 | FOS↑;PRKACA↑;STAT5B↑;OSM↑;GRB2↑;MAP2K1↑;LYN↑;STAT5A↑;MAPK3↑(9) | 6.0E-04 |
 Legionellosis | 51/55 | 13 | CASP1↑;CD14↑;CXCL3↑;HBS1L↑;HSPA1A↑;IL1B↑;MYD88↑;RAB1A↑;TLR2↑;TLR4↑;VCP↑(11) | 6.1E-04 |
 zTuberculosis | 151/179 | 46 | CEBPB↑;CTSD↑;CD14↑;RHOA↑;CLEC4M↑(22) | 6.9E-04 |
 Growth hormone receptor signaling | 17/20 | 1 | IRS2↑;CSH1↑;SOCS3↑;STAT5B↑;LYN↑;STAT5A↑(6) | 6.9E-04 |
 Oncostatin_M | 37/40 | 9 | CEBPB↑;FOS↑;OSMR↑;SOCS3↑;JUNB↑;STAT5B↑;OSM↑;GRB2↑;MAPK3↑(9) | 7.5E-04 |
 IL3 Signaling Pathway | 47/40 | 13 | MAP2K1↑;LYN↑;GRB2↑;PRKACA↑;HCK↑;MAPK3↑;STAT5B↑;VAV1↑;FOS↑;STAT5A↑(10) | 1.2E-03 |
 Endogenous Toll-like receptor signaling | 25/27 | 5 | CD14↑;TLR4↑;RHOA↑;TLR2↑;TLR1↑;MYD88↑;TLR6↑(7) | 1.2E-03 |
 Salmonella infection | 73/86 | 20 | MYD88↑;ACTB↑;RAB7↑;FOS↑;CASP1↑;CXCL3↑;ARPC4↑;IFNGR2↑;CD14↑;MYH14↑;TLR4↑;MAPK3↑;IL1B↑(13) | 1.4E-03 |
 Kit receptor signaling pathway | 57/59 | 11 | MAP2K1↑;LYN↑;GRB2↑;GRB7↑;JUNB↑;MAPK3↑;STAT5A↑;STAT5B↑;RPS6KA1↑;VAV1↑;FOS↑(11) | 1.6E-03 |
 Toll-like receptor signaling pathway | 84/102 | 18 | IL1B↑;MAPK3↑;CD14↑;TLR6↑;MAP2K1↑;IRF7↑;TLR1↑;IKBKE↑;TLR2↑;IFNAR1↑;TLR4↑;FADD↑;FOS↑;MYD88↑(14) | 1.8E-03 |
 Cytoplasmic Ribosomal Proteins | 85/88 | 73 | RPS18 ↓; RPL27↓;RPL27A↓;RPL10A ↓; RPL19↓;RPL18↓;RPLP1↓;RPL34 ↓; RPS8↓;RPL13A↓;RPS6KA1↑;RPL11↓;RPS29↓;RPS27↓(14) | 2.0E-03 |