Skip to main content

Table 4 Top 15 significant pathways associated with short-term exposure

From: Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure

Pathway

Effective/ total size

# ↓ genes

Contributing genes (#)§

P-value

Women

 IL12-mediated signaling events

57/67

33

TBX21↓;CD247↓;MAPK14↑;CCL4↓;CCR5↓(20)

1.8E-06

 role of mef2d in t-cell apoptosis

28/31

25

CD247↓;ZAP70↓;FYN↓;LAT↓;CD3E↓;CABIN1↓;PPP3CC↓;LCK↓;PLCG1↓;CAPN2↓;CD3D↓(11)

1.2E-04

 T cell receptor signaling pathway

96/104

52

CD247↓;PDCD1↓;MAPK14↑;ZAP70↓;FYN↓(22)

8.0E-04

 Ribosome

128/135

100

RPLP2↓;MRPL16 ↓; RPL36↓;RPL35↓;RPL18↓(27)

8.6E-04

 Natural killer cell mediated cytotoxicity

104/134

50

CD247↓;HCST↓;ZAP70↓;FYN↓;LAT↓(23)

1.0E-03

 Downstream signaling in naïve CD8+ T cells

52/71

33

CD247↓;IL2RB↓;EOMES↓;CD8A↓;CD3E↓;PRF1↓;TNFRSF4↓;PTPN7↓;STAT4↓;GZMB↓;BRAF↑;MAPK3↑;CD3D↓;MAPK1↑(14)

1.4E-03

 Formation of a pool of free 40S subunits

94/151

71

RPLP2↓;RPL36↓;RPL35↓;RPL18↓;RPLP1↓(21)

1.5E-03

 Primary immunodeficiency

32/36

24

ZAP70↓;ADA↓;RFXAP↓;DCLRE1C↓;CD8A↓;CD3E↓;CD19↓;ICOS↓;LCK↓;CD3D↓(10)

2.0E-03

 TCR signaling in naïve CD8+ T cells

54/58

35

RASGRP2↓;CD247↓;ZAP70↓;FYN↓;LAT↓;CARD11↓;CD8A↓;CBL↑;RASGRP1↓;CD3E↓;PRF1↓;LCK↓;PLCG1↓;CD3D↓(14)

2.0E-03

 Mitochondrial translation (elongation)*

84/85

72

MRPL38 ↓; MRPL16 ↓; MRPS9 ↓; MRPL4 ↓; MRPS26↓ (19)

2.1E-03

 NF-κB signaling pathway

86/91

43

PARP1↓;TRAF2↓;ZAP70↓;CCL4↓;TRAF5↓(19)

2.8E-03

 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

64/132

41

CD247↓;HCST↓;ICAM4↑;ITGB7↓;CD8A↓;CD96↓;KIR2DL2↓;

CD3E↓;CD19↓;KIR3DL1↓;KLRD1↓;KIR3DL2↓;ITGB1↓;ITGA4↓;CD3D↓(15)

4.2E-03

 Busulfan Pathway, Pharmacodynamics

30/36

16

BNIP3 ↓; CHEK2↓;BCL2L1 ↑; MLH1 ↓; FMO5↑;LTBR↑;GSTP1↓;GGT1↑;MPG↓(9)

4.5E-03

 Cell cycle

116/124

63

ZBTB17↓;ANAPC1↓;CDK4↓;MCM7↓;CHEK2↓(23)

4.6E-03

 Downregulation of SMAD2/3:SMAD4 transcriptional activity

20/21

10

PARP1↓;NCOR2↓;RPS27A↓;SMAD3↓;UBB↑;PPM1A↑;NEDD4L↑(7)

4.6E-03

Men

 Meiotic recombination

53/64

3

HIST1H3C↑;HIST1H2B↑;HIST2H3A↑;HIST1H2B↑;HIST3H2B↑(22)

1.3E-12

 Cytokine Signaling in Immune system

156/198

49

STAT2↑;IRS2↑;CSH1↑;PELI1↑;EIF4E3↑(24)

1.7E-04

 Osteoclast differentiation

120/131

25

CYBA↑;FCGR3B↑;FOSL2↑;GRB2↑;IFNAR1↑(20)

2.0E-04

 Phagosome

135/155

35

ATP6V1E1↑;CD14↑;CYBA↑;CLEC4M↑;FCAR↑(21)

3.7E-04

 GMCSF-mediated signaling events

36/41

10

FOS↑;PRKACA↑;STAT5B↑;OSM↑;GRB2↑;MAP2K1↑;LYN↑;STAT5A↑;MAPK3↑(9)

6.0E-04

 Legionellosis

51/55

13

CASP1↑;CD14↑;CXCL3↑;HBS1L↑;HSPA1A↑;IL1B↑;MYD88↑;RAB1A↑;TLR2↑;TLR4↑;VCP↑(11)

6.1E-04

 zTuberculosis

151/179

46

CEBPB↑;CTSD↑;CD14↑;RHOA↑;CLEC4M↑(22)

6.9E-04

 Growth hormone receptor signaling

17/20

1

IRS2↑;CSH1↑;SOCS3↑;STAT5B↑;LYN↑;STAT5A↑(6)

6.9E-04

 Oncostatin_M

37/40

9

CEBPB↑;FOS↑;OSMR↑;SOCS3↑;JUNB↑;STAT5B↑;OSM↑;GRB2↑;MAPK3↑(9)

7.5E-04

 IL3 Signaling Pathway

47/40

13

MAP2K1↑;LYN↑;GRB2↑;PRKACA↑;HCK↑;MAPK3↑;STAT5B↑;VAV1↑;FOS↑;STAT5A↑(10)

1.2E-03

 Endogenous Toll-like receptor signaling

25/27

5

CD14↑;TLR4↑;RHOA↑;TLR2↑;TLR1↑;MYD88↑;TLR6↑(7)

1.2E-03

 Salmonella infection

73/86

20

MYD88↑;ACTB↑;RAB7↑;FOS↑;CASP1↑;CXCL3↑;ARPC4↑;IFNGR2↑;CD14↑;MYH14↑;TLR4↑;MAPK3↑;IL1B↑(13)

1.4E-03

 Kit receptor signaling pathway

57/59

11

MAP2K1↑;LYN↑;GRB2↑;GRB7↑;JUNB↑;MAPK3↑;STAT5A↑;STAT5B↑;RPS6KA1↑;VAV1↑;FOS↑(11)

1.6E-03

 Toll-like receptor signaling pathway

84/102

18

IL1B↑;MAPK3↑;CD14↑;TLR6↑;MAP2K1↑;IRF7↑;TLR1↑;IKBKE↑;TLR2↑;IFNAR1↑;TLR4↑;FADD↑;FOS↑;MYD88↑(14)

1.8E-03

 Cytoplasmic Ribosomal Proteins

85/88

73

RPS18 ↓; RPL27↓;RPL27A↓;RPL10A ↓; RPL19↓;RPL18↓;RPLP1↓;RPL34 ↓; RPS8↓;RPL13A↓;RPS6KA1↑;RPL11↓;RPS29↓;RPS27↓(14)

2.0E-03

  1. # ↓ Number of down-regulated genes. §If more than 15 contributing genes only the top 5 is given. Mitochondrial pathways are marked with an asterisk and MitoCarta genes are indicated in bold type. IL: Interleukin; MEF2D: myocyte enhancer factor 2D; SMAD2,3,4: SMAD family member 2,3,4; GMCSF: Granulocyte-macrophage colony-stimulating factor