Skip to main content

Table 6 Association between expression levels of the selected genes and PM exposure in women (n = 94) and men (n = 75) of the validation cohort

From: Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure

Sex

Gene symbol

FC (95%CI)

P-val

FC (95%CI)

P-val

FC (95%CI)

P-val

FC (95%CI)

P-val

FC (95%CI)

P-val

FC (95%CI)

P-val

Short-term PM10

Short-term PM2.5

Medium-term PM10

Medium-term PM2.5

Long-term PM10

Long-term PM2.5

Women

Mt genome

  POLG

0.76 (0.57,1.00)

0.06

0.75 (0.57,1.00)

0.05

0.65 (0.39,1.10)

0.11

0.57 (0.32,1.01)

0.06

0.90 (0.78,1.03)

0.12

0.62 (0.45,0.86)

0.005$$

  STOML2

1.13 (0.92,1.37)

0.25

1.11 (0.91,1.35)

0.32

0.95 (0.68,1.34)

0.78

0.95 (0.65,1.39)

0.80

1.03 (0.94,1.13)

0.57

1.21 (0.97,1.51)

0.09

  DNAJA3

0.92 (0.81,1.05)

0.23

0.90 (0.79,1.03)

0.13

0.79 (0.63,0.99)

0.04

0.72 (0.56,0.93)

0.01$

0.96 (0.90,1.02)

0.22

0.88 (0.76,1.03)

0.11

  LONP1

0.84 (0.66,1.09)

0.20

0.84 (0.65,1.08)

0.19

0.64 (0.40,1.00)

0.05

0.55 (0.34,0.90)

0.02$

0.91 (0.80,1.03)

0.15

0.70 (0.52,0.93)

0.02$

ETC

  COX7C

1.22 (0.85,1.77)

0.28

1.19 (0.83,1.72)

0.35

1.50 (0.78,2.86)

0.22

1.56 (0.76,3.22)

0.23

1.19 (1.01,1.41)

0.04

1.82 (1.23,2.70)

0.004$$

  UQCRH

1.32 (0.90,1.93)

0.16

1.29 (0.88,1.89)

0.19

1.29 (0.66,2.49)

0.46

1.42 (0.69,2.94)

0.35

1.14 (0.96,1.37)

0.15

1.81 (1.20,2.71)

0.006$$

  NDUFA13

1.15 (0.89,1.50)

0.30

1.12 (0.87,1.46)

0.38

1.01 (0.65,1.59)

0.95

1.03 (0.63,1.69)

0.90

1.05 (0.93,1.19)

0.45

1.37 (1.03,1.81)

0.03

Men

Mt genome

  POLG

0.94 (0.86, 1.03)

0.18 a

0.95 (0.87, 1.04)

0.33 a

0.90 (0.77, 1.04)

0.16 a

0.90 (0.77, 1.05)

0.17 a

0.96 (0.92, 1.01)

0.09 a

0.91 (0.82, 1.01)

0.07 a

  STOML2

0.96 (0.86, 1.08)

0.52

0.98 (0.88, 1.1)

0.78

0.88 (0.73, 1.06)

0.17

0.88 (0.72, 1.07)

0.19

1.01 (0.96, 1.06)

0.76

0.99 (0.87, 1.12)

0.88

  DNAJA3

1.01 (0.92, 1.10)

0.85

1.02 (0.94,1.11)

0.61

1.08 (0.94, 1.24)

0.29

1.08 (0.94, 1.26)

0.29

1.03 (0.99, 1.07)

0.22

1.05 (0.96, 1.16)

0.27

  LONP1

0.90 (0.81, 1.11)

0.52 b

0.98 (0.84, 1.14)

0.82 b

0.86 (0.67, 1.11)

0.25 b

0.89 (0.68, 1.15)

0.37 b

0.93 (0.87, 1.00)

0.04 b

0.80 (0.68, 0.94)

0.01 b

ETC

  COX7C

1.09 (0.85, 1.40)

0.49

1.11 (0.88, 1.41)

0.38

1.17 (0.78, 1.75)

0.46

1.23 (0.81, 1.88)

0.34

1.08 (0.96, 1.21)

0.190

1.23 (0.94, 1.60)

0.14

  UQCRH

1.14 (0.92, 1.41)

0.25

1.16 (0.94, 1.44)

0.16

1.39 (0.97, 1.98)

0.07

1.41 (0.97, 2.04)

0.07

1.12 (1.01, 1.24)

0.04

1.32 (1.04, 1.69)

0.03

  NDUFA13

1.03 (0.93, 1.15)

0.58

1.05 (0.95, 1.17)

0.36

1.14 (0.96, 1.35)

0.14

1.13 (0.95, 1.36)

0.18

1.05 (1.00, 1.10)

0.04

1.13 (1.01, 1.27)

0.04

  1. FC Fold changes for an increase in PM of 10 μg/m3 (short- and medium-term) and 2 μg/m3 (long-term). Adjusted for age, BMI, smoking status, educational level, and time of blood sampling, temperature, WBC count, and percentage of neutrophils. Mt.: mitochondrial
  2. a3 outliers with relatively low POLG expression removed
  3. b1 outlier with relatively high LONP1 expression removed. Results including the outlier were similar (long-term PM2.5 p-val = 0.007). FDR-adjusted p-values <0.05$$ and <0.10$