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Table 7 Odds ratios (OR) of amyotrophic lateral sclerosis for historical proximity to agricultural fields in tertiles of current exposurea

From: Pesticide exposure assessed through agricultural crop proximity and risk of amyotrophic lateral sclerosis

 

Total

Emilia-Romagna

Sicliy

 

I

II

III

I

II

III

I

II

III

Total agricultural land

 Cut off (%)

<28.1

28.1-77.8

>77.8

<30.8

30.8-78.4

78.4

<11.2

11.2-74.7

>74.7

 Cases/Controls

339/1192

98/257

92/257

190/580

78/220

75/220

156/612

15/37

15/37

 OR (95% CI)

1.00

1.27

(0.96, 1.69)

1.20

(0.91, 1.60)

1.00

1.09

(0.80, 1.50)

1.04

(0.76, 1.42)

1.00

1.51

(0.81, 2.82)

1.60

(0.86, 2.99)

Vineyards

               

 Cut off (%)

<12.4

12.4-25.1

>25.1

<12.4

12.4-24.0

>24.0

<0.1

0.1-99.9

>99.9

 Cases/Controls

507/1625

12/41

10/40

321/940

11/40

11/40

186/685

0/1

0/0

 OR (95% CI)

1.00

0.79

(0.40, 1.55)

0.77

(0.38, 1.56)

1.00

0.76

(0.38, 1.54)

0.81

(0.41, 1.61)

-

    

All Orchards

 Cut off (%)

<8.2

8.2-41.0

>41.0

<5.4

5.4-32.5

>32.5

<13.7

13.7-63.5

>63.5

 Cases/Controls

499/1624

14/41

16/41

332/985

8/17

3/18

168/640

6/23

12/23

 OR (95% CI)

1.00

1.00

(0.54, 1.88)

1.41

(0.78, 2.53)

1.00

1.16

(0.49, 2.74)

0.50

 

1.00

0.91

(0.36, 2.30)

1.99

(0.97, 4.07)

Orchards (not citrus)

 Cut off (%)

>6.8

6.8-36.6

>36.6

<6.8

6.8-34.8

>34.8

<13.7

13.7-99.9

>99.9

 Cases/Controls

518/1667

8/20

3/19

332/985

8/17

3/18

186/684

0/2

0/0

 OR (95% CI)

1.00

1.01

(0.44, 2.34)

0.49

(0.14, 1.67)

1.00

1.16

(0.49, 2.74)

0.50

(0.15, 1.74)

-

    

Citrus orchards

 Cut off (%)

          

<14.6

14.6-63.5

>63.5

 Cases/Controls

          

168/643

6/22

12/21

 OR (95% CI)

          

1.00

0.94

(0.37, 2.39)

2.19

(1.05, 4.54)

Arable and Veg. crops

 Cut off (%)

<25.7

25.7-65.7

>65.7

 

<27.3

27.3-65.9

>65.9

<7.1

7.1-24.6

>24.6

 Cases/Controls

381/1288

67/210

81/208

196/613

66/203

81/204

186/677

0/5

0/4

 OR (95% CI)

1.00

0.99

(0.72, 1.37)

1.21

(0.88, 1.66)

1.00

1.03

(0.74, 1.42)

1.26

(0.92, 1.76)

-

    

Arable crops

 Cut off (%)

     

<27.3

27.3-65.9

>65.9

     

 Cases/Controls

     

196/614

66/203

81/203

     

 OR (95% CI)

     

1.00

1.03

(0.74, 1.42)

1.27

(0.92, 1.74)

     

Vegetables crops

 Cut off (%)

     

<11.2

11.2-23.3

>23.3

     

 Cases/Controls

     

342/1018

1/1

0/1

     

 OR (95% CI)

     

1.00

4.01

(0.25, 64.11)

-

      

Olive groves

 Cut off (%)

          

<8.5

8.5-18.6

>18.6

 Cases/Controls

          

183/683

0/2

 

3/1

 OR (95% CI)

          

1.00

-

 

12.01

(1.25, 115.45)

  1. aTertile cutpoints based on exposure of subjects having proximity to crops >0, with subjects having exposure = 0 included in the bottom tertile. OR computed using a conditional logistic regression model. Some estimates could not be computed because of too few exposed subjects
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Environmental Health

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