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Table 7 Odds ratios (OR) of amyotrophic lateral sclerosis for historical proximity to agricultural fields in tertiles of current exposurea

From: Pesticide exposure assessed through agricultural crop proximity and risk of amyotrophic lateral sclerosis

  Total Emilia-Romagna Sicliy
  I II III I II III I II III
Total agricultural land
 Cut off (%) <28.1 28.1-77.8 >77.8 <30.8 30.8-78.4 78.4 <11.2 11.2-74.7 >74.7
 Cases/Controls 339/1192 98/257 92/257 190/580 78/220 75/220 156/612 15/37 15/37
 OR (95% CI) 1.00 1.27 (0.96, 1.69) 1.20 (0.91, 1.60) 1.00 1.09 (0.80, 1.50) 1.04 (0.76, 1.42) 1.00 1.51 (0.81, 2.82) 1.60 (0.86, 2.99)
Vineyards                
 Cut off (%) <12.4 12.4-25.1 >25.1 <12.4 12.4-24.0 >24.0 <0.1 0.1-99.9 >99.9
 Cases/Controls 507/1625 12/41 10/40 321/940 11/40 11/40 186/685 0/1 0/0
 OR (95% CI) 1.00 0.79 (0.40, 1.55) 0.77 (0.38, 1.56) 1.00 0.76 (0.38, 1.54) 0.81 (0.41, 1.61) -     
All Orchards
 Cut off (%) <8.2 8.2-41.0 >41.0 <5.4 5.4-32.5 >32.5 <13.7 13.7-63.5 >63.5
 Cases/Controls 499/1624 14/41 16/41 332/985 8/17 3/18 168/640 6/23 12/23
 OR (95% CI) 1.00 1.00 (0.54, 1.88) 1.41 (0.78, 2.53) 1.00 1.16 (0.49, 2.74) 0.50   1.00 0.91 (0.36, 2.30) 1.99 (0.97, 4.07)
Orchards (not citrus)
 Cut off (%) >6.8 6.8-36.6 >36.6 <6.8 6.8-34.8 >34.8 <13.7 13.7-99.9 >99.9
 Cases/Controls 518/1667 8/20 3/19 332/985 8/17 3/18 186/684 0/2 0/0
 OR (95% CI) 1.00 1.01 (0.44, 2.34) 0.49 (0.14, 1.67) 1.00 1.16 (0.49, 2.74) 0.50 (0.15, 1.74) -     
Citrus orchards
 Cut off (%)            <14.6 14.6-63.5 >63.5
 Cases/Controls            168/643 6/22 12/21
 OR (95% CI)            1.00 0.94 (0.37, 2.39) 2.19 (1.05, 4.54)
Arable and Veg. crops
 Cut off (%) <25.7 25.7-65.7 >65.7   <27.3 27.3-65.9 >65.9 <7.1 7.1-24.6 >24.6
 Cases/Controls 381/1288 67/210 81/208 196/613 66/203 81/204 186/677 0/5 0/4
 OR (95% CI) 1.00 0.99 (0.72, 1.37) 1.21 (0.88, 1.66) 1.00 1.03 (0.74, 1.42) 1.26 (0.92, 1.76) -     
Arable crops
 Cut off (%)       <27.3 27.3-65.9 >65.9      
 Cases/Controls       196/614 66/203 81/203      
 OR (95% CI)       1.00 1.03 (0.74, 1.42) 1.27 (0.92, 1.74)      
Vegetables crops
 Cut off (%)       <11.2 11.2-23.3 >23.3      
 Cases/Controls       342/1018 1/1 0/1      
 OR (95% CI)       1.00 4.01 (0.25, 64.11) -       
Olive groves
 Cut off (%)            <8.5 8.5-18.6 >18.6
 Cases/Controls            183/683 0/2   3/1
 OR (95% CI)            1.00 -   12.01 (1.25, 115.45)
  1. aTertile cutpoints based on exposure of subjects having proximity to crops >0, with subjects having exposure = 0 included in the bottom tertile. OR computed using a conditional logistic regression model. Some estimates could not be computed because of too few exposed subjects