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Table 4 Summary of exploratory analyses considering effect modification by BMI, smoking status, and sex where main effects were present

From: Persistent organic pollutants and mortality in the United States, NHANES 1999–2011

Mortality/Exposure

N

Hazard Ratio (95% CI)a

p-value for interaction

Hazard Ratio (95% CI)a

p-value for interaction

  

BMI < 25

BMI ≥ 25

 

Non-Smoker

Current Smoker

 

All-Cause

 β-hexachlorocyclohexane

1397

1.06 (0.82, 1.37)

1.36 (1.15, 1.62)

0.08

1.15 (0.98, 1.34)

1.36 (1.02, 1.8)

0.24

Other-cause

 Trans-nonachlor

1404

1.07 (0.98, 1.17)

1.15 (1.06, 1.26)

0.18

1.1 (1.04, 1.16)

1.14 (0.98, 1.33)

0.59

 p,p’-DDE

1411

1.05 (0.74, 1.47)

1.13 (1.05, 1.22)

0.64

1.15 (1.05, 1.25)

1.03 (0.82, 1.3)

0.39

 Oxychlordane

1312

1.09 (0.99, 1.2)

1.25 (1.12, 1.4)

0.04

1.12 (1.04, 1.2)

1.27 (1.07, 1.51)

0.12

 β-hexachlorocyclohexane

1397

1.21 (0.96, 1.53)

1.35 (1.12, 1.63)

0.38

1.25 (1.02, 1.54)

1.3 (0.85, 1.98)

0.87

Mortality/Exposure

N

Hazard Ratio (95% CI)a

p-value for interaction

Hazard Ratio (95% CI)a

p-value for interaction

  

Female

Male

 

ACR < 30

ACR ≥ 30

 

All-Cause

 β-hexachlorocyclohexane

1397

1.22 (0.97, 1.54)

1.16 (0.96, 1.4)

0.71

1.16 (0.98, 1.39)

1.35 (1.08, 1.68)

0.30

Other-cause

 Trans-nonachlor

1404

1.07 (0.99, 1.15)

1.19 (1.07, 1.33)

0.07

1.08 (1, 1.17)

1.18 (1.01, 1.37)

0.28

 p,p’-DDE

1411

1.05 (0.9, 1.23)

1.38 (1.13, 1.69)

0.01

1.1 (0.97, 1.24)

1.17 (0.98, 1.39)

0.52

 Oxychlordane

1312

1.11 (1.02, 1.19)

1.37 (1.1, 1.7)

0.05

1.13 (1.04, 1.22)

1.18 (0.98, 1.41)

0.64

 β-hexachlorocyclohexane

1397

1.46 (1.15, 1.85)

1.11 (0.89, 1.39)

0.05

1.26 (1.01, 1.56)

1.37 (0.96, 1.96)

0.67

  1. aWeighted to consider complex survey design, adjusted for age, gender, race/ethnicity, education, and smoking status
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Environmental Health

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