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Table 3 B-coefficients for indirect path of PCB body burden to depressive symptoms trough dopamine metabolites HVA/crea and VMA/crea (bootstrapping with N = 5000)

From: Polychlorinated biphenyls and depression: cross-sectional and longitudinal investigation of a dopamine-related Neurochemical path in the German HELPcB surveillance program

Indirect path

Effect

S.E. (boot)

BC Bootstrapping 95% CI

   

Lower limit

Upper limit

Mediator HVA/crea

 LPCB_t1 ➔ HVA/crea_t1 ➔ depressive symptoms_t1

−.01

.04

−.10

.05

 LPCB_t2➔ HVA/crea_t2 ➔ depressive symptoms_t2

−.001

.06

−.11

.13

 LPCB_t1 ➔ HVA/crea_t1 ➔ depressive symptoms_t21

.10

.05

.02

.24

 LPCB_t1➔ HVA/crea_t2 ➔ depressive symptoms_t2

.06

.08

−.04

.31

 HPCB _t1➔ HVA/crea_t1 ➔ depressive symptoms_t1

−.01

.07

−.21

.10

 HPCB _t2➔ HVA/crea_t2 ➔ depressive symptoms_t2

.03

.08

−.09

.24

 HPCB _t1➔ HVA/crea_t1 ➔ depressive symptoms_t21

.22

.10

.06

.50

 HPCB _t1➔ HVA/crea_t2 ➔ depressive symptoms_t2

.08

.13

−.10

.49

 dlPCB_t1 ➔ HVA/crea_t1 ➔ depressive symptoms_t1

−.01

.05

−.15

.08

 dlPCB_t2 ➔ HVA/crea_t2 ➔ depressive symptoms_t2

.02

.07

−.08

.20

 dlPCB_t1 ➔ HVA/crea_t1 ➔ depressive symptoms_t21

.17

.08

.05

.36

 dlPCB_t1 ➔ HVA/crea_t2 ➔ depressive symptoms_t2

.08

.11

−.06

.41

Mediator VMA/crea

 LPCB_t1 ➔ VMA /crea_t1 ➔ depressive symptoms_t1

.00

.01

−.02

.05

 LPCB_t2➔ VMA /crea_t2 ➔ depressive symptoms_t2

−.00

.02

−.05

.04

 LPCB_t1 ➔ VMA /crea_t1 ➔ depressive symptoms_t2

.00

.05

−.06

.10

 LPCB_t1➔ VMA /crea_t2 ➔ depressive symptoms_t2

−.00

.04

−.09

.08

 HPCB _t1➔ VMA /crea_t1 ➔ depressive symptoms_t1

.00

.03

−.04

.08

 HPCB _t2➔ VMA /crea_t2 ➔ depressive symptoms_t2

.00

.03

−.06

.08

 HPCB _t1➔ VMA /crea_t1 ➔ depressive symptoms_t2

−.01

.09

−.08

.21

 HPCB _t1➔ VMA /crea_t2 ➔ depressive symptoms_t2

.00

.07

−.15

.14

 dlPCB_t1 ➔ VMA /crea_t1 ➔ depressive symptoms_t1

−.00

.02

−.59

.04

 dlPCB_t2 ➔ VMA /crea_t2 ➔ depressive symptoms_t2

.00

.03

−.05

.07

 dlPCB_t1 ➔ VMA /crea_t1 ➔ depressive symptoms_t2

.01

.08

−.07

.17

 dlPCB_t1 ➔ VMA /crea_t2 ➔ depressive symptoms_t2

.00

.05

−.10

.12

  1. Notes: PCBs polychlorinated biphenyls, LPCBs lower-chlorinated PCBs, HPCBs higher-chlorinated PCBs, dlPCBs dioxin-like PCBs, HVA homovanillic acid, VMA vanillylmandelic acid, crea creatinine, t1 measurement occasion 1, t2 measurement occasion 2, S.E. (boot) bootstrapped standard error, BC bias corrected, CI confidence interval; 1 significant mediations are in italic (p < .05)
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Environmental Health

ISSN: 1476-069X