Polychlorinated biphenyls and depression: cross-sectional and longitudinal investigation of a dopamine-related Neurochemical path in the German HELPcB surveillance program

Table 5 Results of the mediation analyses of HPCB body burden and depressive symptoms through HVA/crea using MEDIATE macro for SPSS [30]; controlled for age, albumin and traumatic experience

	Coefficient	SE	t	p
Total effect model (DV = depressive symptoms_t2)
HPCBs	.94	.39	2.40	.01
Covariates
Age	−.08	.04	−1.96	.03
Albumin	−.14	.19	−.72	.27
Traumatic experience	1.61	1.36	1.19	.12
Depressive symptoms_t1	.75	.09	8.79	<.001
Model fit
R²	.62			<.001
F	27.45
Effect of IV on HVA (mediator)
HPCBs	−1.84	.82	−2.24	.02
Effect of IV and mediator on depressive symptoms_t2
HVA/crea	−.12	.05	−2.40	.01
HPCBs	.71	.39	1.82	.04
Model fit
R²	.65			<.001
F	25.17
Homogeneity of regression (HPCB*HVA)
R²	.002			.25
F	0.47

Note: DV dependent variable, IV independent variable, t1 measurement occasion 1, t2 measurement occasion 2, HPCBs higher-chlorinated biphenyls, HVA homovanillic acid/creatinine, R ² explained variance, F F-value, SE standard error, t t-value, p p-value (significance)

ISSN: 1476-069X