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Table 4 Adjusted odds ratio of elevated alanine aminotransferase (ALT) levels with increasing inorganic arsenic concentrations by race/ethnicity and by weight status

From: Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults: an association modified by race/ethnicity, NHANES 2005–2014

Model

 

Quartile of Inorganic Arsenic [point estimate (95% Confidence Intervals)]

1st

2nd

3rd

4th

 

N

Cases,(%)1

aOR

Cases,(%)1

aOR (95%CI)

Cases,(%)1

aOR (95%CI)

Cases,(%)1

aOR (95%CI)

All 2

8518

506 (28%)

Ref

644 (31%)

1.2 (0.7, 1.9)

736 (33%)

1.6 (1.0, 2.8)

827 (35%)

2.0 (1.2, 3.4)

Race/Ethnicity 3

Non-Hispanic White

3579

325 (30%)

Ref

310 (32%)

1.1 (0.9, 1.4)

262 (32%)

1.0 (0.8, 1.3)

261(37%)

1.4 (1.1, 1.8)

Non-Hispanic Black

1828

47 (17%)

Ref

92 (21%)

1.2 (0.8, 1.7)

127 (25%)

1.4 (0.9, 2.2)

153 (25%)

1.4 (0.9, 2.1)

Mexican Americans

1624

74 (30%)

Ref

150 (35%)

1.5 (1.0, 2.2)

202 (39%)

1.7 (1.1, 2.6)

191 (44%)

2.0 (1.3, 3.1)

Other Hispanics

770

33 (40%)

Ref

61 (39%)

0.7 (0.3, 1.3)

90 (41%)

0.9 (0.5, 1.7)

112 (36%)

0.6 (0.3, 1.1)

Other or Mixed

717

27 (24%)

Ref

31 (27%)

1.1 (0.5, 2.3)

55 (34%)

1.7 (0.7, 4.2)

110 (34%)

1.7 (0.8, 3.7)

BMI Weight Group 4

Underweight/Normal

3319

146 (19%)

Ref

144 (7%)

0.9 (0.7, 1.3)

168 (20%)

1.1 (0.8, 1.5)

183 (21%)

1.34 (1.0, 1.8)

Overweight

2480

159 (31%)

Ref

183 (31%)

1.0 (0.8, 1.5)

213 (33%)

0.98 (0.7, 1.4)

262 (36%)

1.31 (0.9, 1.9)

Obese

2719

201 (39%)

Ref

317 (46%)

1.4 (1.0, 1.9)

355 (48%)

1.3 (1.0, 1.8)

382 (48%)

1.50 (1.1, 2.0)

Obese Only 4

Non-Hispanic White

1067

134 (44%)

Ref

139 (47%)

1.3 (0.9, 2.1)

129 (50%)

1.3 (0.8, 2.0)

108 (50%)

1.5 (1.0, 2.2)

Non-Hispanic Black

726

17 (18%)

Ref

57 (33%)

1.7 (0.9, 3.1)

73 (37%)

2.0 (1.0, 3.9)

95 (37%)

2.0 (1.1, 3.8)

Mexican Americans

554

29 (44%)

Ref

82 (57%)

1.9 (1.0, 3.5)

102 (53%)

1.4 (0.7, 2.9)

94 (61%)

1.9 (1.0, 3.5)

Other Hispanics

255

7 (37%)

Ref

31 (57%)

2.8 (0.6, 13.4)

40 (57%)

3.3 (0.8, 13.9)

55 (49%)

1.9 (0.5, 7.5)

Other or Mixed

117

14 (50%)

Ref

8 (44%)

0.4 (0.1, 2.2)

11 (50%)

0.5 (0.1, 2.6)

30 (61%)

0.9 (0.3, 3.3)

  1. All model adjusted for age, survey cycle, gender, PIR, race/ethnicity, BMI Weight status, and interactions (race/ethnicity*iAS, BMI weight status*iAS)
  2. 1%cases = # with elevated ALT divided by the total in the arsenic exposure quartile + race/ethnic or weight category subgroup
  3. 2Adjusted for age, survey cycle, gender, PIR, BMI Weight status, and race/ethnicity
  4. 3Adjusted for age, survey cycle, gender, PIR, and BMI Weight status
  5. 4Adjusted for age, survey cycle, gender, PIR, and race/ethnicity
  6. Note: High blood-ALT levels were defined as >25 IU/L for boys ≤17 years and >22 IU/L for girls ≤17 years. In adults, high ALT was defined >30 IU/L in males and >19 IU/L in females