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Table 3 Adjusted associations between phenols, phthalate metabolites and IQ of boys at 5 years (N = 452)

From: In-utero exposure to phenols and phthalates and the intelligence quotient of boys at 5 years

  Verbal IQ Performance IQ
β 95% CI P-value Corrected P-valuec β 95% CI P-value Corrected P-valuec
Phenols
 Parabensa −0.031 [− 0.138; 0.076] 0.57 0.81 0.037 [−0.096; 0.170] 0.58 0.81
 2,5 Dichlorophenol 0.015 [− 0.073; 0.102] 0.74 0.88 0.007 [−0.101; 0.115] 0.90 0.96
 Benzophenone-3 0.066 [−0.025; 0.156] 0.16 0.71 0.006 [−0.105; 0.118] 0.91 0.96
 Bisphenol A −0.045 [−0.138; 0.047] 0.33 0.71 −0.059 [−0.173; 0.054] 0.31 0.71
 Triclosan 0.078 [−0.012; 0.168] 0.09 0.71 0.0001 [−0.112; 0.112] 1.00 1.00
Phthalates
 MEP −0.055 [−0.153; 0.042] 0.27 0.71 −0.023 [−0.144; 0.097] 0.70 0.88
 MBP −0.094 [−0.229; 0.041] 0.17 0.71 −0.078 [−0.243; 0.088] 0.36 0.71
 MIBP 0.045 [−0.057; 0.147] 0.39 0.71 0.042 [−0.084; 0.168] 0.51 0.81
 MCPP 0.136 [0.006; 0.266] 0.04 0.71 0.094 [−0.036; 0.254] 0.25 0.71
 MBZP 0.005 [−0.098; 0.108] 0.92 0.96 0.089 [−0.037; 0.216] 0.17 0.71
 MCOP −0.076 [−0.178; 0.026] 0.15 0.71 −0.055 [−0.181; 0.070] 0.39 0.71
 MCNP 0.019 [−0.083; 0.121] 0.72 0.88 0.060 [−0.066; 0.186] 0.35 0.71
 DEHPb −0.042 [−0.143; 0.059] 0.41 0.71 −0.034 [−0.158; 0.090] 0.59 0.81
  1. Root Mean Square Error of Approximation (RMSEA): 0.048 (95% Confidence Interval (CI): 0.043; 0.053), Comparative Fit Index (CFI) = 0.930, Tucker-Lewis fit index (TLI) = 0.921
  2. Abbreviations: CI confidence interval, MBP mono-n-butyl phthalate, MBZP monobenzyl phthalate, MCNP monocarboxy-isononyl phthalate, MCOP monocarboxy-isooctyl phthalate, MCPP mono(3-carboxypropyl) phthalate, MEP monoethyl phthalate, MIBP mono-isobutyl phthalate
  3. aLatent variable of methyl, ethyl, propyl and butyl parabens
  4. bLatent variable of di(2-ethylhexyl) phthalate metabolites: Mono(2-ethyl-5-carboxypentyl) phthalate, Mono(2-ethyl-5-hydroxyhexyl) phthalate, Mono(2-ethyl-5-oxohexyl) phthalate and Mono(2-ethylhexyl) phthalate
  5. cP-values corrected for multiple comparisons using the Benjamini and Hochberg false discovery rate method. β = change in IQ SD associated with 1-SD increase in ln-transformed concentrations