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Table 3 Adjusted associations between phenols, phthalate metabolites and IQ of boys at 5 years (N = 452)

From: In-utero exposure to phenols and phthalates and the intelligence quotient of boys at 5 years

 

Verbal IQ

Performance IQ

β

95% CI

P-value

Corrected

P-valuec

β

95% CI

P-value

Corrected

P-valuec

Phenols

 Parabensa

−0.031

[− 0.138; 0.076]

0.57

0.81

0.037

[−0.096; 0.170]

0.58

0.81

 2,5 Dichlorophenol

0.015

[− 0.073; 0.102]

0.74

0.88

0.007

[−0.101; 0.115]

0.90

0.96

 Benzophenone-3

0.066

[−0.025; 0.156]

0.16

0.71

0.006

[−0.105; 0.118]

0.91

0.96

 Bisphenol A

−0.045

[−0.138; 0.047]

0.33

0.71

−0.059

[−0.173; 0.054]

0.31

0.71

 Triclosan

0.078

[−0.012; 0.168]

0.09

0.71

0.0001

[−0.112; 0.112]

1.00

1.00

Phthalates

 MEP

−0.055

[−0.153; 0.042]

0.27

0.71

−0.023

[−0.144; 0.097]

0.70

0.88

 MBP

−0.094

[−0.229; 0.041]

0.17

0.71

−0.078

[−0.243; 0.088]

0.36

0.71

 MIBP

0.045

[−0.057; 0.147]

0.39

0.71

0.042

[−0.084; 0.168]

0.51

0.81

 MCPP

0.136

[0.006; 0.266]

0.04

0.71

0.094

[−0.036; 0.254]

0.25

0.71

 MBZP

0.005

[−0.098; 0.108]

0.92

0.96

0.089

[−0.037; 0.216]

0.17

0.71

 MCOP

−0.076

[−0.178; 0.026]

0.15

0.71

−0.055

[−0.181; 0.070]

0.39

0.71

 MCNP

0.019

[−0.083; 0.121]

0.72

0.88

0.060

[−0.066; 0.186]

0.35

0.71

 DEHPb

−0.042

[−0.143; 0.059]

0.41

0.71

−0.034

[−0.158; 0.090]

0.59

0.81

  1. Root Mean Square Error of Approximation (RMSEA): 0.048 (95% Confidence Interval (CI): 0.043; 0.053), Comparative Fit Index (CFI) = 0.930, Tucker-Lewis fit index (TLI) = 0.921
  2. Abbreviations: CI confidence interval, MBP mono-n-butyl phthalate, MBZP monobenzyl phthalate, MCNP monocarboxy-isononyl phthalate, MCOP monocarboxy-isooctyl phthalate, MCPP mono(3-carboxypropyl) phthalate, MEP monoethyl phthalate, MIBP mono-isobutyl phthalate
  3. aLatent variable of methyl, ethyl, propyl and butyl parabens
  4. bLatent variable of di(2-ethylhexyl) phthalate metabolites: Mono(2-ethyl-5-carboxypentyl) phthalate, Mono(2-ethyl-5-hydroxyhexyl) phthalate, Mono(2-ethyl-5-oxohexyl) phthalate and Mono(2-ethylhexyl) phthalate
  5. cP-values corrected for multiple comparisons using the Benjamini and Hochberg false discovery rate method. β = change in IQ SD associated with 1-SD increase in ln-transformed concentrations
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Environmental Health

ISSN: 1476-069X