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Table 1 Distribution of maternal 1976 serum TCDD levels (ppt, lipid-adjusted) by maternal and child-based characteristics; SWHS, Italy, 1976–2016

From: Prenatal exposure to TCDD and atopic conditions in the Seveso second generation: a prospective cohort study

 

N (%) N = 676 children of 438 mothers

1976 Serum TCDD (ppt) Median (IQR)

Maternal characteristics (n = 438)

 Age at explosion (years)*

  < 11

137 (31.3)

162.0 (57.8–327.0)

  11–17

143 (32.7)

55.0 (26.7–111.0)

  18+

158 (36.1)

43.8 (22.0–99.5)

 Atopic history

  Yes

91 (20.8)

85.2 (35.0–222.0)

  No

347 (79.2)

63.3 (29.1–166.0)

 Age at pregnancy (years)

  < 26

140 (20.7)

44.1 (21.0–103.5)

  26–29

194 (28.7)

62.3 (29.6–160.0)

  30–33

177 (26.2)

76.2 (34.4–214.0)

  34+

165 (24.4)

76.9 (37.5–214.0)

 BMI (kg/m2) closest to birth year

  < 25 (underweight/normal)

477 (70.6)

67.5 (30.8–185.0)

  25–29 (overweight)

148 (21.9)

49.9 (23.7–164.0)

  30+ (obese)

51 (7.5)

86.7 (28.4–162.0)

 Smoking during pregnancy a

  Yes

63 (9.3)

55.2 (20.7–109.0)

  No

609 (90.1)

66.8 (30.2–185.0)

Child Characteristics (n = 676)

 Pre-term birth (< 37 weeks)

  Yes

46 (6.8)

90.2 (33.2–245.0)

  No

630 (93.2)

64.3 (29.6–173.0)

 Season of birth

  Spring

174 (25.7)

55.5 (29.0–196.0)

  Summer

167 (24.7)

66.8 (29.9–174.0)

  Fall

171 (25.3)

66.7 (28.6–176.0)

  Winter

164 (24.3)

72.6 (33.4–170.0)

 Breastfeeding duration (months)

  < 1

214 (31.7)

60.3 (28.6–150.0)

  1–4

250 (37.0)

69.9 (30.6–173.0)

  5+

212 (31.4)

66.2 (34.4–212.0)

 Birth order

  1

401 (59.3)

70.0 (31.0–185.0)

  2

236 (34.9)

63.3 (29.3–172.0)

  3+

39 (5.8)

49.9 (19.5–105.0)

 Sex

  Males

336 (49.7)

60.1 (26.9–158.5)

  Females

340 (50.3)

75.0 (33.2–196.0)

 Age at follow-up*

  2–13

161 (23.8)

166.0 (49.0–433.0)

  14–22

167 (24.7)

66.2 (33.2–163.4)

  23–30

171 (25.3)

60.0 (29.4–123.0)

  31–39

177 (26.2)

40.7 (21.3–85.2)

 Primary wage earner education at follow-up

  Less than high school

200 (29.6)

65.3 (29.8–153.5)

  High school

251 (37.1)

75.2 (33.3–247.0)

  Greater than high school

225 (33.3)

60.0 (23.9–140.0)

  1. aNumbers do not add to 100% because of missing data. 4 missing values for maternal smoking during pregnancy
  2. *p < 0.05 (ANOVA significant difference in log10TCDD by covariates)