Early life Triclosan exposure and child adiposity at 8 Years of age: a prospective cohort study

Table 3 Adjusted difference in adiposity measures at age 8 years per 10-fold-increase in urinary triclosan concentrations among HOME Study children: Adjusted for all triclosan measures^{a, b,c,d}

Adiposity Outcome and Triclosan Measure Timing^a	All, Adjusted Difference (95% CI)	Boys, Adjusted Difference ^c (95% CI)	Girls, Adjusted Difference ^c (95% CI)	EMM p-value^d
BMI z-score
Prenatal	−0.06 (− 0.28, 0.16)	0.05 (− 0.30, 0.39)	−0.13 (− 0.42, 0.15)	0.43
Early Childhood	0.11 (−0.24, 0.46)	0.11 (− 0.50, 0.72)	−0.05 (− 0.42, 0.15)	0.57
8 Years	− 0.07 (− 0.27, 0.12)	−0.14 (− 0.46, 0.17)	−0.10 (− 0.34, 0.14)	0.90
Waist Circumference
Prenatal	− 1.6 (− 3.6, 0.4)	− 0.8 (− 3.4, 1.7)	−1.7 (− 4.2, 0.7)	0.67
Early Childhood	1.3 (−1.8, 4.3)	1.8 (− 2.8, 6.4)	−0.9 (− 4.4, 2.6)	0.35
8 Years	− 0.5 (− 2.3, 1.2)	− 1.5 (− 3.9, 0.8)	−0.9 (− 3.0, 1.2)	0.43
Body Fat %
Prenatal	−0.9 (− 2.4, 0.5)	− 0.5 (− 2.1, 1.0)	−0.7 (− 2.7, 1.3)	0.84
Early Childhood	0.6 (− 1.7, 2.8)	0.6 (−2.2, 3.4)	−1.0 (− 3.8, 1.8)	0.70
8 Years	0.1 (− 1.2, 1.4)	−0.9 (− 2.3, 0.6)	− 0.1 (− 1.9, 1.6)	0.52

^aAlong with mutually adjusting for all three triclosan measures, all estimates are adjusted for maternal race, education, marital status, age at delivery, income, prenatal vitamin use, delivery method, maternal BMI, and prenatal serum cotinine concentrations. Both waist circumference and body fat percentage have also been adjusted for child’s age. All urinary triclosan concentrations have been creatinine standardized
^bFor all analysis All: N = 210, Boys: N = 94, Girls: N = 116
^cEffect estimates and 95% CI were derived from a sex-stratified model
^dEffect measure modification p-values were determined using a two sample z-test to compare the effect estimates for boys and girls

ISSN: 1476-069X