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Table 3 Associations of lung function measurements at age 5 years in relation to weighted road density within a 50 m radius of home adjusted for potential confounders stratified by fish oil supplementation

From: Childhood fish oil supplementation modifies associations between traffic related air pollution and allergic sensitisation

  No fish oil supplementation Fish oil supplementation p-value for interaction
N Mean Difference 95% CI p-value N Mean Difference 95% CI p-value  
log (FEV1 pre bronchodilator (L)) 154 −0.04 −0.09−0.01 0.083 147 −0.04 −0.08−0.01 0.100 0.760
log (FEV1 post bronchodilator (L)) 151 − 0.03 − 0.08−0.01 0.150 146 −0.03 − 0.08−0.02 0.188 0.808
log (FVC pre bronchodilator (L)) 154 −0.05 −0.10−0.01 0.102 147 −0.03 −0.08−0.01 0.171 0.854
log (FVC post bronchodilator (L)) 151 −0.03 −0.08−0.03 0.306 146 −0.01 −0.06−0.04 0.641 0.950
FEV1/FVC ratio pre bronchodilator 154 −0.05 −0.10−0.00 0.037 147 −0.03 −0.07−0.01 0.126 0.932
FEV1/FVC ratio post bronchodilator 151 −0.04 −0.08−0.01 0.102 146 −0.03 −0.08−0.01 0.175 0.908
pre Peak Expiratory Flow (PEF) 154 −0.05 −0.10−0.00 0.073 147 −0.03 −0.07−0.02 0.237 0.903
post Peak Expiratory Flow (PEF) 151 −0.03 −0.07−0.02 0.240 146 −0.01 −0.05−0.03 0.727 0.795
Pre forced expiratory flow at 50% vital capacity (FEF50) 154 0 −0.02−0.01 0.623 147 −0.01 −0.02−0.01 0.549 0.935
Post forced expiratory flow at 50% vital capacity (FEF50) 151 −0.01 −0.02−0.01 0.349 146 −0.02 −0.04−0.00 0.022 0.408
Pre forced expiratory flow at mid-expiratory phase (FEF25–75) 102 5.30 −6.24−16.85 0.364 99 −0.32 −14.53−13.88 0.964 0.386
Post forced expiratory flow at mid-expiratory phase (FEF25–75) 100 6.23 −6.04−18.50 0.316 98 −0.49 −14.22−13.24 0.944 0.410
  1. All models are adjusted for age at spirometry, height at spirometry, weight at spirometry, sex, father’s education, mother’s education, environmental tobacco smoke exposure, breastfed to 6 months, any dog owned by 5 or 8 years, any cat owned by 5 or 8 years, maternal smoking in pregnancy, gas cooking at home
  2. Interaction term of fish oil supplementation with weighted road density was added as a separate term into a random intercept Poisson model. Mean difference, Relative Risks (RRs) and 95% confidence intervals (95% CI) represent increase in risk per unit increase in weighted road density, representing 100 m local road or 33.3 m of motorway within 50 m of the home. N = number of children