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Table 4 Repeated measures analysis of combined age 5 and 8 years: Associations of selected allergic and respiratory outcomes in relation to weighted road density within a 50 m radius of home stratified by fish oil supplementation and restricted to non-movers between age 5 and 8 years

From: Childhood fish oil supplementation modifies associations between traffic related air pollution and allergic sensitisation

Total IgE

No fish oil supplementation

Fish oil supplementation

p-value for interaction

N

Mean difference

95% CI

p-value

N

Mean difference

95% CI

p-value

 

Total IgE (kU/L)

95

−0.023

−0.28–0.24

0.860

95

−0.11

−0.36–0.15

0.414

0.786

Questionnaire variables

 

RR

   

RR

   

 Doctor diagnosed asthma

126

1.11

0.66–1.89

0.688

111

0.94

0.64–1.40

0.781

0.763

 Ever had doctor diagnosed asthma

126

1.03

0.66–1.62

0.889

111

0.78

0.54–1.16

0.231

0.387

 Wheeze in the last 12 months

126

1.17

0.74–1.87

0.499

111

0.87

0.64–1.21

0.433

0.472

 Wheeze in the last 12 months & asthma

126

1.23

0.65–2.36

0.525

111

0.71

0.46–1.13

0.155

0.308

 Cough more than 4 times in the last 12 months

126

1.26

0.83–1.90

0.280

111

1.19

0.85–1.67

0.308

0.955

 Doctor diagnosed Eczema

126

1.33

0.85–2.06

0.209

111

1.25

0.85–1.83

0.260

0.749

 Eczema in the last 12 months

125

1.57

0.88–2.78

0.123

110

1.01

0.58–1.77

0.973

0.467

 Doctor diagnosed allergic rhinitis

126

2.02

0.90–4.51

0.086

111

2.38

1.01–5.62

0.048

0.606

Positive Skin prick tests

 Any of 11 inhalant and food allergens

121

1.62

1.08–2.45

0.021

107

0.75

0.53–1.09

0.131

0.031

 Inhalant allergen

121

1.69

1.10–2.60

0.016

107

0.77

0.54–1.11

0.165

0.031

 Ingested allergen

121

1.49

0.45–4.89

0.510

107

1.00

0.53–1.90

0.996

0.800

 House dust mite (HDM)

121

2.36

1.34–4.14

0.002

107

0.97

0.67–1.42

0.902

0.026

 Alternaria tenuis

121

0.88

0.37–2.05

0.762

107

0.71

0.38–1.35

0.299

0.500

 Grass mix

121

1.57

0.63–3.92

0.334

107

0.81

0.43–1.55

0.535

0.406

 Rye Grass

121

1.73

0.78–3.86

0.180

107

0.75

0.35–1.63

0.475

0.206

HDM sensitization

 IL-5 (> 10 pg/ml)

83

2.05

1.26–3.32

0.003

79

0.61

0.40–0.92

0.0186

<0.001

 IL-10 (> 10 pg/ml)

82

1

0.76–1.31

0.996

77

0.87

0.72–1.03

0.112

0.672

  1. All models are adjusted for sex, father’s education, mother’s education, environmental tobacco smoke exposure, breastfed to 6 months, any dog owned by 5 or 8 years, any cat owned by 5 or 8 years, maternal smoking in pregnancy, gas cooking at home
  2. Interaction term of fish oil supplementation with weighted road density was added as a separate term into a random intercept Poisson model. Mean difference, Relative Risks (RRs) and 95% confidence intervals (95% CI) represent increase in risk per unit increase in weighted road density, representing 100 m local road or 33.3 m of motorway within given radius of the home. N = number of children
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Environmental Health

ISSN: 1476-069X