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Table 4 Repeated measures analysis of combined age 5 and 8 years: Associations of selected allergic and respiratory outcomes in relation to weighted road density within a 50 m radius of home stratified by fish oil supplementation and restricted to non-movers between age 5 and 8 years

From: Childhood fish oil supplementation modifies associations between traffic related air pollution and allergic sensitisation

Total IgE No fish oil supplementation Fish oil supplementation p-value for interaction
N Mean difference 95% CI p-value N Mean difference 95% CI p-value  
Total IgE (kU/L) 95 −0.023 −0.28–0.24 0.860 95 −0.11 −0.36–0.15 0.414 0.786
Questionnaire variables   RR     RR    
 Doctor diagnosed asthma 126 1.11 0.66–1.89 0.688 111 0.94 0.64–1.40 0.781 0.763
 Ever had doctor diagnosed asthma 126 1.03 0.66–1.62 0.889 111 0.78 0.54–1.16 0.231 0.387
 Wheeze in the last 12 months 126 1.17 0.74–1.87 0.499 111 0.87 0.64–1.21 0.433 0.472
 Wheeze in the last 12 months & asthma 126 1.23 0.65–2.36 0.525 111 0.71 0.46–1.13 0.155 0.308
 Cough more than 4 times in the last 12 months 126 1.26 0.83–1.90 0.280 111 1.19 0.85–1.67 0.308 0.955
 Doctor diagnosed Eczema 126 1.33 0.85–2.06 0.209 111 1.25 0.85–1.83 0.260 0.749
 Eczema in the last 12 months 125 1.57 0.88–2.78 0.123 110 1.01 0.58–1.77 0.973 0.467
 Doctor diagnosed allergic rhinitis 126 2.02 0.90–4.51 0.086 111 2.38 1.01–5.62 0.048 0.606
Positive Skin prick tests
 Any of 11 inhalant and food allergens 121 1.62 1.08–2.45 0.021 107 0.75 0.53–1.09 0.131 0.031
 Inhalant allergen 121 1.69 1.10–2.60 0.016 107 0.77 0.54–1.11 0.165 0.031
 Ingested allergen 121 1.49 0.45–4.89 0.510 107 1.00 0.53–1.90 0.996 0.800
 House dust mite (HDM) 121 2.36 1.34–4.14 0.002 107 0.97 0.67–1.42 0.902 0.026
 Alternaria tenuis 121 0.88 0.37–2.05 0.762 107 0.71 0.38–1.35 0.299 0.500
 Grass mix 121 1.57 0.63–3.92 0.334 107 0.81 0.43–1.55 0.535 0.406
 Rye Grass 121 1.73 0.78–3.86 0.180 107 0.75 0.35–1.63 0.475 0.206
HDM sensitization
 IL-5 (> 10 pg/ml) 83 2.05 1.26–3.32 0.003 79 0.61 0.40–0.92 0.0186 <0.001
 IL-10 (> 10 pg/ml) 82 1 0.76–1.31 0.996 77 0.87 0.72–1.03 0.112 0.672
  1. All models are adjusted for sex, father’s education, mother’s education, environmental tobacco smoke exposure, breastfed to 6 months, any dog owned by 5 or 8 years, any cat owned by 5 or 8 years, maternal smoking in pregnancy, gas cooking at home
  2. Interaction term of fish oil supplementation with weighted road density was added as a separate term into a random intercept Poisson model. Mean difference, Relative Risks (RRs) and 95% confidence intervals (95% CI) represent increase in risk per unit increase in weighted road density, representing 100 m local road or 33.3 m of motorway within given radius of the home. N = number of children