Childhood and adolescent phenol and phthalate exposure and the age of menarche in Latina girls

Table 3 Menarche hazard ratio (95% CI) between tertiles of each EDC biomarker across puberty^a

Biomarker	Middle vs Lowest Tertile	Highest vs Middle Tertile	Highest vs Lowest Tertile	Trend^b (p-value)
2,4-Dichlorophenol	1.03 (0.79, 1.35)	1.01 (0.79, 1.30)	1.04 (0.80, 1.37)	0.701
BPA	1.06 (0.81, 1.38)	0.86 (0.67, 1.11)	0.91 (0.70, 1.20)	0.695
MBP	0.95 (0.74, 1.23)	1.00 (0.76, 1.31)	0.95 (0.69, 1.31)	0.749
MBzP	0.70* (0.54, 0.93)	1.16 (0.88, 1.55)	0.82 (0.62, 1.08)	0.155
MCNP	0.99 (0.77, 1.27)	0.91 (0.67, 1.23)	0.89 (0.67, 1.19)	0.433
MCOP	0.94 (0.72, 1.22)	0.99 (0.75, 1.30)	0.93 (0.68, 1.27)	0.661
MCPP	0.92 (0.67, 1.26)	0.84 (0.63, 1.13)	0.77 (0.57, 1.04)	0.116
MEP	1.00 (0.74, 1.34)	1.20 (0.88, 1.62)	1.19 (0.90, 1.57)	0.212
Methyl Paraben	0.96 (0.71, 1.29)	1.14 (0.84, 1.54)	1.09 (0.81, 1.47)	0.575
MHBP	0.94 (0.72, 1.23)	1.10 (0.88, 1.39)	1.04 (0.76, 1.41)	0.808
MHiBP	0.98 (0.76, 1.26)	1.09 (0.86, 1.39)	1.07 (0.82, 1.39)	0.654
MiBP	0.85 (0.63, 1.15)	1.13 (0.85, 1.50)	0.96 (0.74, 1.26)	0.763
Propyl Paraben	0.83 (0.60, 1.13)	1.20 (0.85, 1.68)	0.99 (0.73, 1.33)	0.918
Triclosan	0.85 (0.66, 1.10)	1.05 (0.84, 1.30)	0.90 (0.67, 1.20)	0.536

^aAccelerated failure time model adjusting for BMI Z-score and maternal education; restricting to the subset of associations for which there was no significant interaction between Tanner stage at biomarker measurement and biomarker concentration on timing of menarche (p > 0.05)
^bTrend evaluated by modeling the log(median) concentration within tertiles as a continuous variable
*p < 0.05, **p < 0.01, ***p < 0.001

ISSN: 1476-069X