Childhood and adolescent phenol and phthalate exposure and the age of menarche in Latina girls

Table 5 Menarche hazard ratio (95% CI) between tertiles of biomarker stratified by Tanner stage at measurement^a

Biomarker	Tanner Stage	Middle vs Lowest Tertile	Highest vs Middle Tertile	Highest vs Lowest Tertile	Trend^b (p-value)
2,5-Dichlorophenol
	1	1.35 (0.93, 1.98)	1.17 (0.81, 1.68)	1.58* (1.09, 2.29)	0.019*
	4	1.16 (0.79, 1.69)	0.79 (0.55, 1.14)	0.91 (0.62, 1.35)	0.521
Benzophenone-3
	1	1.58** (1.12, 2.22)	0.89 (0.60, 1.34)	1.41 (0.96, 2.06)	0.142
	4	0.87 (0.61, 1.24)	1.07 (0.74, 1.54)	0.93 (0.63, 1.37)	0.743
ΣDEHP
	1	0.43*** (0.31, 0.61)	1.56* (1.09, 2.25)	0.67* (0.46, 0.98)	0.140
	4	0.93 (0.64, 1.36)	1.52* (1.01, 2.28)	1.42 (0.93, 2.17)	0.083
MECPP
	1	0.43*** (0.30, 0.62)	1.63** (1.15, 2.33)	0.71 (0.47, 1.05)	0.232
	4	0.92 (0.64, 1.34)	1.53* (1.02, 2.31)	1.41 (0.93, 2.15)	0.082
MEHHP
	1	0.47*** (0.33, 0.68)	1.44 (1.00, 2.09)	0.68* (0.47, 0.99)	0.064
	4	1.05 (0.73, 1.52)	1.29 (0.87, 1.90)	1.36 (0.89, 2.06)	0.148
MEHP
	1	0.78 (0.54, 1.14)	0.94 (0.64, 1.38)	0.73 (0.50, 1.09)	0.122
	4	1.05 (0.74, 1.49)	1.40 (0.93, 2.10)	1.47 (0.98, 2.20)	0.061
MEOHP
	1	0.43*** (0.30, 0.62)	1.92*** (1.34, 2.75)	0.83 (0.59, 1.17)	0.313
	4	1.07 (0.73, 1.55)	1.30 (0.87, 1.95)	1.39 (0.91, 2.12)	0.120
MMP
	1	1.31 (0.89, 1.93)	0.82 (0.55, 1.22)	1.07 (0.74, 1.56)	0.672
	4	0.98 (0.68, 1.42)	1.45* (1.01, 2.10)	1.42* (1.02, 1.99)	0.032*

^aEstimating Tanner stage-specific association between biomarker and age of menarche adjusting BMI Z-score and maternal education, including an interaction between biomarker tertile and Tanner stage; restricted to subset of associations for which the interaction with Tanner stage was significant (p < 0.05)
^bTrend evaluated by modeling the log(median) concentration within tertiles as a continuous variable
*p < 0.05, **p < 0.01, ***p < 0.001

ISSN: 1476-069X