Phthalate Metabolite | Logistic* | Cox | AFT |
---|
OR | 95% CI | HR | 95% CI | % Change | 95% CI |
---|
MEHP |
1.50
|
(1.10, 2.07)
| 1.07 | (0.98, 1.17) | −0.79% | (−1.67, 0.09%) |
MEHHP | 1.05 | (0.75, 1.47) | 1.04 | (0.94, 1.15) | −0.51% | (−1.01, 0.32%) |
MEOHP | 1.23 | (0.87, 1.75) | 1.09 | (0.98, 1.21) | −0.76% | (−1.74, 0.23%) |
MECPP |
1.66
|
(1.20, 2.30)
|
1.21
|
(1.09, 1.33)
|
−1.19%
|
(−2.11, −0.26%)
|
Σ DEHP |
1.47
|
(1.06, 2.03)
|
1.14
|
(1.04, 1.26)
|
−1.03%
|
(−1.95, −0.01%)
|
MBzP | 1.27 | (0.79, 1.65) |
1.15
|
(1.03, 1.27)
| −0.60% | (−1.63, 0.43%) |
MBP | 1.35 | (0.99, 1.87) |
1.17
|
(1.05, 1.29)
| −0.74% | (−1.75, 0.28%) |
MiBP | 0.98 | (0.66, 1.45) | 1.00 | (0.90, 1.12) | 0.30% | (−0.82, 1.44%) |
MEP | 1.22 | (0.87, 1.71) | 1.01 | (0.91, 1.12) | −0.11% | (−1.06, 0.86%) |
MCPP | 1.27 | (0.93, 1.72) |
1.10
|
(1.01, 1.20)
| −0.28% | (−1.18, 0.62%) |
- Phthalates were averaged across the first three visits and log-transformed. All models were adjusted for average specific gravity, maternal age at first visit, race, and education. The single-pollutant models for MBzP, MBP, MiBP, MEP, and MCPP are also adjusted for health insurance provider. Bolded cells indicate significant (p < 0.05) odds ratios (OR), hazard ratios (HR), and percent changes (% Change). Odds ratios, hazard ratios and percent changes are all calculated on IQR (Interquartile Range) scale. Abbreviations: CI, Confidence Interval; Logistic, Logistic Regression; Cox, Cox Proportional Hazards Model; AFT, Accelerated Failure Time Model; MEHP, Mono-(2-ethyl)-hexyl phthalate; MEHHP, Mono-(2-ethyl-5-hydroxyhexyl) phthalate; MEOHP, Mono-(2-ethyl-5-oxohexyl) phthalate; MECPP, Mono-(2-ethyl-5-carboxypentyl) phthalate; Σ DEHP, Summed DEHP metabolites; MBzP, Mono-benzyl phthalate; MBP, Mono-n-butyl phthalate; MiBP, Mono-isobutyl phthalate; MEP, Mono-ethyl phthalate; MCPP, Mono-(3-carboxypropyl) phthalate. *Results are similar to Ferguson and colleagues (2014) [14]