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Table 3 Changes in lung function, inflammatory markers, and biochemical analyses

From: Exposure to volatile organic compounds and airway inflammation

  Before move (n = 34) After move (n = 34) p-value
Lung function testsa
 FEV1, L 2.51 (0.69–4.05) 2.44 (1.39–3.96) 0.688
 FEV1, % 90 (30–119) 93 (64–118) 0.410
 FVC, L 3.14 (1.01–5.06) 3.03 (1.82–5.19) 0.688
 FVC, % 90 (33–118) 91 (70–111) 0.448
 FEV1/FVC 80 (65–89) 80 (67–90) 0.734
 FEV25–75, L/s 2.71 (0.39–6.08) 2.57 (0.72–4.95) 0.899
 FEV25–75, % 90 (19–168) 94 (33–190) 0.959
FeNO (ppm) 21 (11–43) 19 (7–44) 0.040
uLTE4 (pg/ml) 252.4 (36.8–5889.5) 460.6 (15.0–5570.9) 0.005
FeNO / uLTE4 11.1 (1.2–145.4) 20.7 (0.7–206.3) 0.004
Oxidative stress biomarkers
 MDA (μmol/g Cr.) 1.3 (0.4–8.8) 1.4 (0.4–3.3) 0.578
 8-OHdG (ng/mg Cr.) 3.4 (0.6–8.2) 3.0 (0.3–8.3) 0.351
VOC metabolites
 t,t-MA (μg/g Cr) 85.8 (30.2–623.8) 68.0 (9.5–347.0) 0.012
 HA (mg/g Cr) 204.4 (8.6–1984.9) 272.9 (18.0–1978.1) 0.714
 MA (μg/g Cr) 183.5 (68.7–440.6) 215.1 (71.3–2481.6) 0.118
 PGA (μg/g Cr) 47.4 (4.9–431.6) 63.4 (3.9–431.8) 0.966
 o-MHA (μg/g Cr) 60.7 (12.2–307.0) 99.7 (30.3–299.6) 0.000
 m-MHA (μg/g Cr) 101.7 (25.9–912.2) 164.6 (80.4–453.6) 0.002
 p-MHA (μg/g Cr) 52.4 (17.5–401.3) 88.6 (30.2–630.9) 0.000
  1. aMedian (range)
  2. † Sputum eosinophilia, eosinophil ≥3% in induced sputum
  3. AR allergic rhinitis
  4. Bold typeface indicates P < 0.05