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Table 10 Effects of glyphosate or Roundup Bioflow exposure on hormone ratios in males (Mean ± SEM)

From: The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Hormone ratios (ng/ml)

6-week cohort

13-week cohort

Control

Glyphosate

Roundup

Control

Glyphosate

Roundup

No. of males examined

8 (8)

8 (8)

8 (8)

10 (10)

10 (10)

10 (10)

fT/TT (x 10−3)

12.5 ± 1.35

8.67 ± 0.83a *

10.8 ± 0.45b

53.0 ± 11.1c

85.0 ± 27.5c

24.7 ± 4.03*

DHT/TT

0.658 ± 0.081

0.511 ± 0.087

0.614 ± 0.122d

2.195 ± 0.37

2.490 ± 0.70

0.65 ± 0.15c **

E2/TT (× 10− 3)

1.01 ± 0.19d

2.65 ± 1.15

10.1 ± 5.17d

1.59 ± 1.23c

0.52 ± 0.14e

1.84 ± 0.42c

TT/SHBG (× 10− 4)

12.90 ± 1.35

12.23 ± 3.25

10.1 ± 1.37d

88.30 ± 31.86

86.59 ± 33.21

40.68 ± 9.36

E2/SHBG (× 10− 6)

1.24 ± 0.23d

3.90 ± 2.21

7.18 ± 2.66*

3.87 ± 2.69c

1.20 ± 0.003f

6.66 ± 1.25

  1. *Statistically significant (p < 0.05) with Kruskal-Wallis’ tests
  2. **Statistically significant (p < 0.01) with Kruskal-Wallis’ tests
  3. a6 out 8
  4. b5 out 8
  5. c9 out 10
  6. d7 out 8
  7. e8 out 10
  8. f7 out 10