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Table 10 Effects of glyphosate or Roundup Bioflow exposure on hormone ratios in males (Mean ± SEM)

From: The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Hormone ratios (ng/ml) 6-week cohort 13-week cohort
Control Glyphosate Roundup Control Glyphosate Roundup
No. of males examined 8 (8) 8 (8) 8 (8) 10 (10) 10 (10) 10 (10)
fT/TT (x 10−3) 12.5 ± 1.35 8.67 ± 0.83a * 10.8 ± 0.45b 53.0 ± 11.1c 85.0 ± 27.5c 24.7 ± 4.03*
DHT/TT 0.658 ± 0.081 0.511 ± 0.087 0.614 ± 0.122d 2.195 ± 0.37 2.490 ± 0.70 0.65 ± 0.15c **
E2/TT (× 10− 3) 1.01 ± 0.19d 2.65 ± 1.15 10.1 ± 5.17d 1.59 ± 1.23c 0.52 ± 0.14e 1.84 ± 0.42c
TT/SHBG (× 10− 4) 12.90 ± 1.35 12.23 ± 3.25 10.1 ± 1.37d 88.30 ± 31.86 86.59 ± 33.21 40.68 ± 9.36
E2/SHBG (× 10− 6) 1.24 ± 0.23d 3.90 ± 2.21 7.18 ± 2.66* 3.87 ± 2.69c 1.20 ± 0.003f 6.66 ± 1.25
  1. *Statistically significant (p < 0.05) with Kruskal-Wallis’ tests
  2. **Statistically significant (p < 0.01) with Kruskal-Wallis’ tests
  3. a6 out 8
  4. b5 out 8
  5. c9 out 10
  6. d7 out 8
  7. e8 out 10
  8. f7 out 10