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Table 11 Effects of glyphosate or Roundup Bioflow exposure on hormone ratios in females

From: The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Hormone ratios (ng/ml) 6 week cohort 13 week cohort
Control Glyphosate Roundup Control Glyphosate Roundup
No. of females examined 8 (8) 8 (8) 8 (8) 10 (10) 10 (10) 9 (10)
fT/ TT (x 10−3) 9.17 ± 0.48a 8.12 ± 0.55b 11.90 ± 2.37c 19.3 ± 5.20 19.0 ± 2.80 17.0 ± 1.66
DHT/ TT 0.428 ± 0.036 0.481 ± 0.060c 0.718 ± 0.173c 0.794 ± 0.11 0.702 ± 0.10 0.383 ± 0.07d**
E2/ TTe 0.012 ± 0.0003 0.045 ± 0.014 0.066 ± 0.028c 0.019 ± 0.005 0.035 ± 0.012 0.068 ± 0.015d
TT/SHBG (× 10− 4) 7.85 ± 1.02 8.00 ± 1.26 7.81 ± 1.35c 5.35 ± 0.62 7.27 ± 0.98 7.5 ± 0.61*
E2/SHBG (× 10− 5)e 1.69 ± 0.78 3.51 ± 1.00 7.28 ± 2.55 1.90 ± 0.89 2.89 ± 1.41 4.87 ± 1.10 d
  1. *Statistically significant (p < 0.05) with Kruskal-Wallis’ tests
  2. **Statistically significant (p < 0.01) with Kruskal-Wallis’ tests
  3. a6 out 8
  4. b5 out 8
  5. c7 out of 8
  6. d9 out 10
  7. eNot statistically evaluated due to insufficient sample size after clustering on the basis of the estrous cycle