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Table 6 Organ weights of male offspring

From: The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

  6-week cohort 13-week cohort
Control Glyphosate Roundup Control Glyphosate Roundup
No. of males examined 8 8 8 10 10 10
Body weight (g)a 321 ± 19 326 ± 16 317 ± 23 458 ± 19 454 ± 19 449 ± 15
Adrenal glandsa, b 0.070 ± 0.014 [0.022 ± 0.005] 0.071 ± 0.015 [0.022 ± 0.004] 0.063 ± 0.009 [0.020 ± 0.002] 0.085 ± 0.025 [0.019 ± 0.005] 0.083 ± 0.024 [0.018 ± 0.005] 0.144 ± 0.190 [0.032 ± 0.041]
Testisa, b 1.475 ± 0.052 [0.461 ± 0.023] 1.474 ± 0.077 [0.453 ± 0.023] 1.459 ± 0.100 [0.460 ± 0.017] 1.568 ± 0.065 [0.342 ± 0.013] 1.529 ± 0.076 [0.337 ± 0.013] 1.562 ± 0.068 [0.347 ± 0.012]
Epididymisa, b 0.370 ± 0.041 [0.115 ± 0.011] 0.343 ± 0.040 [0.105 ± 0.010] 0.368 ± 0.038 [0.116 ± 0.006] 0.595 ± 0.039 [0.130 ± 0.008] 0.563 ± 0.043 [0.124 ± 0.008] 0.553 ± 0.026* [0.123 ± 0.006]
Bladder/Prostatea, b 0.563 ± 0.080 [0.176 ± 0.026] 0.561 ± 0.099 [0.173 ± 0.036] 0.506 ± 0.090 [0.159 ± 0.022] 0.967 ± 0.086 [0.211 ± 0.024] 0.897 ± 0.160 [0.197 ± 0.033] 0.906 ± 0.190 [0.202 ± 0.045]
Seminal vesicles and coagulating glanda, b 1.129 ± 0.129 [0.353 ± 0.045] 1.110 ± 0.291 [0.339 ± 0.083] 1.235 ± 0.135 [0.389 ± 0.029] 2.049 ± 0.418 [0.446 ± 0.083] 1.879 ± 0.298 [0.414 ± 0.063] 2.055 ± 0.404 [0.457 ± 0.090]
  1. *Statistically significant with Dunnett’s test (p < 0.05)
  2. aMean ± standard deviation
  3. b:Absolute organ weight (g). In square brackets relative organ weight (organ weight / body weight ratio *100)