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Table 8 Effects of glyphosate or Roundup Bioflow exposure on hormones in males (mean ± SEM)

From: The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

 

6-week cohort

13-week cohort

Control

Glyphosate

Roundup

Control

Glyphosate

Roundup

Serum Hormones

 No. of males examined

8 (8)

8 (8)

8 (8)

10 (10)

10 (10)

10 (10)

 TT (ng/ml)

1.12 ± 0.12

1.02 ± 0.28

0.84 ± 0.11a

8.16 ± 2.86

7.65 ± 2.86

3.76 ± 0.90

 fT (pg/ml)

14.53 ± 2.37

7.45 ± 2.23b

13.12 ± 3.74b

296.70 ± 123.70c

724.24 ± 419.22c

90.40 ± 29.44

 DHT (pg/ml)

761.11 ± 136.21

575.28 ± 238.24

554.29 ± 145.16a

15,709.0 ± 5547.20

16,711.8 ± 6724.5

1980.2 ± 664.68c**

 SHBG (ng/ml)

861.20 ± 30.24

833.24 ± 21.15

856.78 ± 32.39

917.58 ± 16.94

906.36 ± 21.62

906.51 ± 18.89

 E2 (pg/ml)

1.04 ± 0.21a

3.29 ± 1.85

6.19 ± 2.28b

3.66 ± 2.57c

1.08 ± 0.02d

6.00 ± 1.11

Plasma Hormones

 No. of males examined

7 (8)

6 (8)

7 (8)

10 (10)

10 (10)

10 (10)

 FSH (ng/ml)

7.00 ± 1.38

6.43 ± 1.16

7.18 ± 0.68

2.32 ± 0.40e

2.18 ± 0.16f

2.90 ± 0.28f

 LH (ng/ml)

3.76 ± 0.79

2.87 ± 0.63

4.41 ± 0.62

1.20 ± 0.17e

1.25 ± 0.24d

1.40 ± 0.18f

 PRL (ng/ml)

3.83 ± 0.64

3.00 ± 0.64

4.31 ± 1.32

 GH (ng/ml)

6.03 ± 4.32g

23.19 ± 21.17h

4.38 ± 1.94i

 TSH (ng/ml)

4.23 ± 0.76

8.17 ± 1.58*

5.57 ± 0.31b

1.89 ± 0.20

2.53 ± 0.25

3.69 ± 0.42**

 ACTH (pg/ml)

346.67 ± 35.52

255.18 ± 43.29

292.26 ± 26.22

 BDNF (pg/ml)

99.49 ± 25.32b

148.85 ± 37.53

171.79 ± 14.65*

53.83 ± 14.77c

58.07 ± 13.83

45.15 ± 14.64

  1. *Statistically significant (p < 0.05) with Kruskal-Wallis’ tests
  2. **Statistically significant (p < 0.01) with Kruskal-Wallis’ tests
  3. a7 out 8
  4. b6 out 8
  5. c9 out 10
  6. d8 out 10
  7. e6 out 10
  8. f7 out 10
  9. g5 out 8
  10. h3 out 8
  11. i4 out 8