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Table 8 Effects of glyphosate or Roundup Bioflow exposure on hormones in males (mean ± SEM)

From: The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

  6-week cohort 13-week cohort
Control Glyphosate Roundup Control Glyphosate Roundup
Serum Hormones
 No. of males examined 8 (8) 8 (8) 8 (8) 10 (10) 10 (10) 10 (10)
 TT (ng/ml) 1.12 ± 0.12 1.02 ± 0.28 0.84 ± 0.11a 8.16 ± 2.86 7.65 ± 2.86 3.76 ± 0.90
 fT (pg/ml) 14.53 ± 2.37 7.45 ± 2.23b 13.12 ± 3.74b 296.70 ± 123.70c 724.24 ± 419.22c 90.40 ± 29.44
 DHT (pg/ml) 761.11 ± 136.21 575.28 ± 238.24 554.29 ± 145.16a 15,709.0 ± 5547.20 16,711.8 ± 6724.5 1980.2 ± 664.68c**
 SHBG (ng/ml) 861.20 ± 30.24 833.24 ± 21.15 856.78 ± 32.39 917.58 ± 16.94 906.36 ± 21.62 906.51 ± 18.89
 E2 (pg/ml) 1.04 ± 0.21a 3.29 ± 1.85 6.19 ± 2.28b 3.66 ± 2.57c 1.08 ± 0.02d 6.00 ± 1.11
Plasma Hormones
 No. of males examined 7 (8) 6 (8) 7 (8) 10 (10) 10 (10) 10 (10)
 FSH (ng/ml) 7.00 ± 1.38 6.43 ± 1.16 7.18 ± 0.68 2.32 ± 0.40e 2.18 ± 0.16f 2.90 ± 0.28f
 LH (ng/ml) 3.76 ± 0.79 2.87 ± 0.63 4.41 ± 0.62 1.20 ± 0.17e 1.25 ± 0.24d 1.40 ± 0.18f
 PRL (ng/ml) 3.83 ± 0.64 3.00 ± 0.64 4.31 ± 1.32
 GH (ng/ml) 6.03 ± 4.32g 23.19 ± 21.17h 4.38 ± 1.94i
 TSH (ng/ml) 4.23 ± 0.76 8.17 ± 1.58* 5.57 ± 0.31b 1.89 ± 0.20 2.53 ± 0.25 3.69 ± 0.42**
 ACTH (pg/ml) 346.67 ± 35.52 255.18 ± 43.29 292.26 ± 26.22
 BDNF (pg/ml) 99.49 ± 25.32b 148.85 ± 37.53 171.79 ± 14.65* 53.83 ± 14.77c 58.07 ± 13.83 45.15 ± 14.64
  1. *Statistically significant (p < 0.05) with Kruskal-Wallis’ tests
  2. **Statistically significant (p < 0.01) with Kruskal-Wallis’ tests
  3. a7 out 8
  4. b6 out 8
  5. c9 out 10
  6. d8 out 10
  7. e6 out 10
  8. f7 out 10
  9. g5 out 8
  10. h3 out 8
  11. i4 out 8