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Table 2 Epigenetic complexes represented by upregulated genes in arsenic-exposed male fetal placenta

From: Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner

Complex

Components upregulated in male placenta

Function

References

SWI/SNF_BRM-BRG

PBRM1, BRD7, SMARCA4

ATP-dependent chromatin remodeling

[19]

COMPASS-like MLL3, 4

KMT2D, KMT2C, KDM6A

H3K4 methylation and H3K27 demethylation

[19]

SWI/SNF_BRM

SMARCA4, HDAC2, HDAC1

ATP-dependent chromatin remodeling (by homology)

UniProt, [19]

NuA4-related

SRCAP, EP400, BRD8

Histone H4 and H2A acetylation (by homology)

UniProt, [20, 21]

  1. The EpiFactors database [18] was used to identify epigenetic regulatory complexes, the expression of whose components in male fetal placenta was positively associated with U-As. Complexes containing three U-As-associated genes are shown
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Environmental Health

ISSN: 1476-069X