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Table 3 Cross-sectional associations between phthalate biomarker concentrations and overweight and obesity compared to underweight/normal within the Women’s Health Initiative (N=997)

From: Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study

Phthalate biomarker, ng/mL

Overweight

OR (95% CI)

Obese

OR (95% CI)

Model 1a

Model 2b

Model 1a

Model 2b

MEP

 2.80 - 33.10

ref

ref

ref

ref

 33.20 - 67.90

0.98 (0.64-1.51)

1.01 (0.64-1.58)

0.79 (0.50-1.24)

0.71 (0.42-1.19)

 68.10 - 159.00

0.91 (0.58-1.43)

0.85 (0.53-1.37)

0.81 (0.51-1.28)

0.64 (0.38-1.08)

 161.00 - 26000.00

0.86 (0.54-1.35)

0.80 (0.50-1.28)

0.71 (0.45-1.14)

0.56 (0.33-0.96)

 P trend

0.48

0.29

0.20

0.04

MBP

 0.28 - 12.00

ref

ref

ref

ref

 12.10 - 23.60

1.06 (0.69-1.64)

1.12 (0.72-1.77)

1.12 (0.70-1.80)

1.28 (0.75-2.17)

 23.70 - 46.70

1.05 (0.67-1.65)

1.12 (0.70-1.79)

1.37 (0.86-2.21)

1.55 (0.90-2.64)

 46.80 - 3600.00

0.82 (0.51-1.33)

0.94 (0.57-1.56)

0.89 (0.54-1.48)

1.11 (0.63-1.97)

 P trend

0.45

0.81

0.78

0.64

MHBP

 0.28 - 0.90

ref

ref

ref

ref

 1.00 - 1.90

1.02 (0.66-1.57)

1.04 (0.66-1.64)

0.91 (0.57-1.44)

1.01 (0.60-1.69)

 2.00 - 3.90

0.86 (0.55-1.36)

0.94 (0.59-1.51)

0.94 (0.59-1.50)

1.11 (0.65-1.90)

 4.00 - 490.00

0.57 (0.36-0.91)

0.63 (0.39-1.03)

0.46 (0.28-0.75)

0.60 (0.34-1.05)

 P trend

0.02

0.07

0.004

0.10

ΣDBP, μmol/L

 0.002 - 0.065

ref

ref

ref

ref

 0.0652 - 0.132

1.01 (0.67-1.53)

1.06 (0.69-1.63)

1.19 (0.76-1.87)

1.25 (0.76-2.07)

 0.133 - 0.264

0.89 (0.57-1.39)

0.97 (0.61-1.53)

1.22 (0.77-1.94)

1.40 (0.84-2.36)

 0.265 - 18.255

0.84 (0.52-1.37)

0.93 (0.56-1.56)

0.92 (0.55-1.54)

1.13 (0.63-2.01)

 P trend

0.45

0.76

0.86

0.56

MiBP

 0.14 - 1.00

ref

ref

ref

ref

 1.10 - 2.10

1.13 (0.75-1.70)

1.18 (0.77-1.80)

1.26 (0.82-1.94)

1.38 (0.84-2.24)

 2.20 - 4.10

1.68 (1.08-2.62)

1.73 (1.08-2.76)

1.89 (1.19-3.00)

1.97 (1.17-3.31)

 4.20 - 212.00

1.99 (1.21-3.27)

2.27 (1.35-3.81)

1.93 (1.15-3.23)

2.30 (1.28-4.13)

 P trend

0.003

0.001

0.005

0.003

MHiBP

 0.28 - 0.40

ref

ref

ref

ref

 0.50 - 0.80

0.92 (0.61-1.40)

0.96 (0.63-1.48)

0.97 (0.64-1.49)

0.97 (0.60-1.57)

 0.90 - 1.60

1.19 (0.76-1.85)

1.23 (0.77-1.96)

0.92 (0.57-1.46)

0.88 (0.52-1.50)

 1.70 - 91.70

1.03 (0.63-1.69)

1.21 (0.72-2.03)

0.70 (0.41-1.18)

0.86 (0.48-1.56)

 P trend

0.69

0.36

0.20

0.57

ΣDiBP, μmol/L

 0.002 - 0.0057

ref

ref

ref

ref

 0.006 - 0.0123

0.81 (0.54-1.24)

0.87 (0.56-1.340

0.86 (0.55-1.34)

0.97 (0.59-1.61)

 0.0124 - 0.0247

1.36 (0.87-2.13)

1.44 (0.90-2.29)

1.53 (0.96-2.42)

1.61 (0.95-2.72)

 0.0248 - 1.339

1.73 (1.04-2.88)

1.99 (1.16-3.39)

1.49 (0.87-2.53)

1.88 (1.03-3.43)

 P trend

0.01

0.004

0.05

0.02

MBzP

 0.40 - 5.90

ref

ref

ref

ref

 6.00 - 12.00

1.08 (0.71-1.65)

1.21 (0.78-1.87)

2.19 (1.37-3.50)

2.58 (1.52-4.38)

 12.10 - 22.20

0.96 (0.61-1.49)

0.93 (0.59-1.47)

1.67 (1.02-2.74)

1.52 (0.88-2.64)

 22.30 - 3590.00

1.45 (0.89-2.37)

1.58 (0.94-2.66)

2.34 (1.37-4.01)

2.73 (1.48-5.04)

 P trend

0.21

0.18

0.01

0.01

MCPP

 0.14 - 1.70

ref

ref

ref

ref

 1.80 - 3.00

1.18 (0.77-1.81)

1.22 (0.77-1.91)

0.99 (0.62-1.58)

0.98 (0.58-1.67)

 3.10 - 5.40

1.40 (0.89-2.20)

1.52 (0.94-2.42)

1.72 (1.08-2.75)

1.86 (1.10-3.16)

 5.50 - 108.00

1.64 (0.98-2.74)

1.90 (1.10-3.27)

1.58 (0.93-2.68)

1.78 (0.97-3.28)

 P trend

0.05

0.02

0.03

0.02

MEHP

 0.35 - 0.90

ref

ref

ref

ref

 1.00 - 1.90

1.29 (0.84-1.96)

1.45 (0.94-2.26)

1.02 (0.65-1.59)

1.03 (0.62-1.71)

 2.00 - 4.10

1.45 (0.95-2.22)

1.60 (1.02-2.51)

1.32 (0.85-2.04)

1.46 (0.89-2.42)

 4.20 - 367.00

1.43 (0.90-2.27)

1.71 (1.04-2.80)

1.17 (0.73-1.90)

1.31 (0.75-2.27)

 P trend

0.09

0.02

0.36

0.20

MEHHP

 0.60 - 9.20

ref

ref

ref

ref

 9.30 - 17.10

1.20 (0.79-1.83)

1.26 (0.81-1.95)

1.34 (0.85-2.15)

1.22 (0.72-2.05)

 17.20 - 33.00

1.67 (1.09-2.57)

1.80 (1.14-2.83)

2.20 (1.39-3.48)

1.96 (1.17-3.30)

 33.20 - 2830.00

2.10 (1.26-3.49)

2.33 (1.36-3.98)

2.97 (1.76-5.03)

2.93 (1.62-5.31)

 P trend

0.002

0.001

<0.001

<0.001

MEOHP

 0.20 - 5.80

ref

ref

ref

ref

 5.90 - 10.60

1.04 (0.68-1.59)

1.11 (0.71-1.72)

0.99 (0.62-1.58)

0.96 (0.57-1.62)

 10.70 - 20.40

1.72 (1.30-2.66)

1.84 (1.16-2.90)

2.05 (1.30-3.24)

1.89 (1.13-3.16)

 20.50 - 1610.00

1.80 (1.30-2.98)

2.01 (1.19-3.43)

2.19 (1.30-3.67)

2.40 (1.33-4.32)

 P trend

0.006

0.003

<0.001

0.001

MECPP

 1.10 - 12.90

ref

ref

ref

ref

 13.00 - 22.60

1.37 (0.91-2.08)

1.45 (0.94-2.23)

1.52 (0.96-2.41)

1.35 (0.80-2.27)

 22.70 - 41.50

1.96 (1.26-3.04)

1.98 (1.24-3.16)

2.85 (1.79-4.55)

2.48 (1.46-4.19)

 41.60 - 2460.00

2.27 (1.36-3.80)

2.57 (1.49-4.43)

3.15 (1.85-5.37)

3.50 (1.90-6.45)

 P trend

0.001

<0.001

<0.001

<0.001

ΣDEHP, μmol/L

 0.008 - 0.1007

ref

ref

ref

ref

 0.1008 - 0.1827

1.43 (0.95-2.17)

1.58 (1.03-2.44)

1.28 (0.81-2.03)

1.27 (0.76-2.13)

 0.1828 - 0.341

2.22 (1.42-3.47)

2.31 (1.44-3.69)

2.69 (1.69-4.29)

2.33 (1.38-3.94)

 0.343 - 24.419

2.27 (1.35-3.82)

2.72 (1.57-4.72)

2.75 (1.61-4.67)

3.29 (1.80-6.03)

 P trend

0.001

<0.001

<0.001

<0.001

MCOP

 0.14 - 2.10

ref

ref

ref

ref

 2.20 - 3.60

1.78 (1.18-2.67)

2.00 (1.30-3.08)

1.56 (1.00-2.43)

1.50 (0.91-2.49)

 3.70 - 6.50

2.10 (1.32-3.34)

2.06 (1.27-3.34)

2.66 (1.66-4.27)

2.38 (1.40-4.05)

 6.60 - 239.00

2.79 (1.70-4.57)

2.93 (1.74-4.92)

2.66 (1.59-4.46)

2.55 (1.42-4.58)

 P trend

<0.001

<0.001

<0.001

0.001

MCNP

 0.14 - 1.50

ref

ref

ref

ref

 1.60 - 2.60

1.43 (0.95-2.16)

1.52 (0.99-2.34)

1.63 (1.04-2.56)

1.63 (0.98-2.72)

 2.70 - 4.70

1.34 (0.86-2.11)

1.47 (0.92-2.37)

2.12 (1.33-3.39)

2.37 (1.39-4.04)

 4.80 - 91.60

2.00 (1.24-3.22)

2.18 (1.32-3.59)

2.35 (1.42-3.89)

2.64 (1.49-4.67)

 P trend

0.006

0.003

0.001

0.001

  1. Abbreviations used: CI confidence interval, MEP monoethyl phthalate, MBP monobutyl phthalate, MHBP mono-hydroxybutyl phthalate, DBP dibutyl phthalate, MiBP mono-isobutyl phthalate, phthalate MHiBP mono-hydroxyisobutyl phthalate, DiBP di-isobutyl phthalate, MBzP monobenzyl phthalate, MCPP mono(3-carboxypropyl) phthalate, MEHP mono(2-ethylhexyl) phthalate, MEHHP mono(2-ethyl-5-hydroxyhexyl) phthalate, MEOHP mono(2-ethyl-5-oxohexyl), DEHP di(2-ethylhexyl)phthalate, MECPP mono(2-ethyl-5-carboxypentyl) phthalate, MCOP mono-carboxyoctyl phthalate, MCNP mono-carboxynonyl phthalate, OR odds ratio
  2. aAdjusted for creatinine
  3. bAdjusted for creatinine, age, ethnicity, alcohol use, physical activity, smoking status, healthy eating index, dietary energy intake, hormone replacement therapy use, education, income, and history of diabetes, hypertension, dyslipidemia and cardiovascular diseases