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Table 2 Association between the risk of head and neck cancer, globally and by subsite, and exposure to leather dust assessed using a job-exposure matrix. Results from the general questionnaire
| Controls | HNC overall | Oral cavity | Oropharynx | Hypopharynx | Oral cavity, pharynx unspecified | Larynx | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | n | ORa (95% CI) | n | ORa (95% CI) | n | ORa (95% CI) | n | ORa (95% CI) | n | ORa (95% CI) | n | ORa (95% CI) | |
| Exposure to leather dust | |||||||||||||
| Never exposed b | 3476 | 2087 | reference | 433 | reference | 643 | reference | 386 | reference | 141 | reference | 484 | reference |
| Ever exposed c | 75 | 57 | 0.99 (0.62, 1.56) | 9 | 0.71 (0.32, 1.58) | 12 | 0.64 (0.31, 1.29) | 12 | 1.24 (0.61, 2.52) | 5 | 1.47 (0.54, 3.99) | 19 | 1.40 (0.77, 2.56) |
| Maximum probability of exposure (%) | |||||||||||||
| ≤ 50 | 32 | 26 | 1.17 (0.59, 2.31) | 3 | 0.46 (0.10, 2.08) | 8 | 1.21 (0.49, 2.94) | 3 | 0.85 (0.23, 3.07) | 3 | 2.36 (0.63, 8.78) | 9 | 1.60 (0.66, 3.85) |
| > 50 | 43 | 31 | 0.86 (0.47, 1.58) | 6 | 0.86 (0.33, 2.22) | 4 | 0.28 (0.08, 0.97) | 9 | 1.44 (0.61, 3.41) | 2 | 0.93 (0.20, 4.22) | 10 | 1.26 (0.56, 2.83) |
| Maximum level of exposure (mg/m3) | |||||||||||||
| < 3 | 50 | 41 | 1.09 (0.63, 1.89) | 5 | 0.55 (0.18, 1.62) | 10 | 0.82 (0.37, 1.81) | 8 | 1.33 (0.56, 3.14) | 4 | 1.90 (0.62, 5.87) | 14 | 1.58 (0.77, 3.24) |
| ≥ 3 | 25 | 16 | 0.79 (0.35, 1.77) | 4 | 1.01 (0.31, 3.30) | 2 | 0.32 (0.07, 1.48) | 4 | 1.09 (0.32, 3.62) | 1 | 0.75 (0.09, 6.25) | 5 | 1.07 (0.36, 3.17) |
| Cumulative duration of exposure (years) | |||||||||||||
| ≤ 7 | 43 | 45 | 1.22 (0.70, 2.14) | 6 | 0.75 (0.27, 2.04) | 8 | 0.64 (0.26, 1.56) | 11 | 1.75 (0.79–3.86) | 4 | 1.95 (0.63, 6.02) | 16 | 1.86 (0.92, 3.75) |
| > 7 | 32 | 12 | 0.63 (0.28, 1.44) | 3 | 0.67 (0.18, 2.46) | 4 | 0.69 (0.22, 2.16) | 1 | 0.34 (0.04, 2.71) | 1 | 0.75 (0.08, 6.42) | 3 | 0.68 (0.19, 2.45) |
| Cumulative exposure index (mg/m3-years) | |||||||||||||
| ≤ 6 | 38 | 37 | 1.43 (0.78, 2.61) | 5 | 0.81 (0.26, 2.47) | 8 | 0.81 (0.33, 1.98) | 6 | 1.42 (0.53, 3.78) | 4 | 3.04 (0.97, 9.54) | 14 | 2.26 (1.07, 4.76) |
| > 6 | 37 | 20 | 0.60 (0.29, 1.22) | 4 | 0.58 (0.18, 1.82) | 4 | 0.37 (0.12, 1.15) | 6 | 1.01 (0.36, 2.77) | 1 | 0.40 (0.05, 3.25) | 5 | 0.65 (0.23, 1.85) |
