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Table 2 Association between the risk of head and neck cancer, globally and by subsite, and exposure to leather dust assessed using a job-exposure matrix. Results from the general questionnaire

From: Head and neck cancer and occupational exposure to leather dust: results from the ICARE study, a French case-control study

 

Controls

HNC overall

Oral cavity

Oropharynx

Hypopharynx

Oral cavity, pharynx unspecified

Larynx

n

n

ORa (95% CI)

n

ORa (95% CI)

n

ORa (95% CI)

n

ORa (95% CI)

n

ORa (95% CI)

n

ORa (95% CI)

Exposure to leather dust

 Never exposed b

3476

2087

reference

433

reference

643

reference

386

reference

141

reference

484

reference

 Ever exposed c

75

57

0.99 (0.62, 1.56)

9

0.71 (0.32, 1.58)

12

0.64 (0.31, 1.29)

12

1.24 (0.61, 2.52)

5

1.47 (0.54, 3.99)

19

1.40 (0.77, 2.56)

Maximum probability of exposure (%)

 ≤ 50

32

26

1.17 (0.59, 2.31)

3

0.46 (0.10, 2.08)

8

1.21 (0.49, 2.94)

3

0.85 (0.23, 3.07)

3

2.36 (0.63, 8.78)

9

1.60 (0.66, 3.85)

 >  50

43

31

0.86 (0.47, 1.58)

6

0.86 (0.33, 2.22)

4

0.28 (0.08, 0.97)

9

1.44 (0.61, 3.41)

2

0.93 (0.20, 4.22)

10

1.26 (0.56, 2.83)

Maximum level of exposure (mg/m3)

 <  3

50

41

1.09 (0.63, 1.89)

5

0.55 (0.18, 1.62)

10

0.82 (0.37, 1.81)

8

1.33 (0.56, 3.14)

4

1.90 (0.62, 5.87)

14

1.58 (0.77, 3.24)

 ≥ 3

25

16

0.79 (0.35, 1.77)

4

1.01 (0.31, 3.30)

2

0.32 (0.07, 1.48)

4

1.09 (0.32, 3.62)

1

0.75 (0.09, 6.25)

5

1.07 (0.36, 3.17)

Cumulative duration of exposure (years)

 ≤ 7

43

45

1.22 (0.70, 2.14)

6

0.75 (0.27, 2.04)

8

0.64 (0.26, 1.56)

11

1.75 (0.79–3.86)

4

1.95 (0.63, 6.02)

16

1.86 (0.92, 3.75)

 >  7

32

12

0.63 (0.28, 1.44)

3

0.67 (0.18, 2.46)

4

0.69 (0.22, 2.16)

1

0.34 (0.04, 2.71)

1

0.75 (0.08, 6.42)

3

0.68 (0.19, 2.45)

Cumulative exposure index (mg/m3-years)

 ≤ 6

38

37

1.43 (0.78, 2.61)

5

0.81 (0.26, 2.47)

8

0.81 (0.33, 1.98)

6

1.42 (0.53, 3.78)

4

3.04 (0.97, 9.54)

14

2.26 (1.07, 4.76)

 >  6

37

20

0.60 (0.29, 1.22)

4

0.58 (0.18, 1.82)

4

0.37 (0.12, 1.15)

6

1.01 (0.36, 2.77)

1

0.40 (0.05, 3.25)

5

0.65 (0.23, 1.85)

  1. a ORs (odds ratios) adjusted for age, sex, area of residence, socioeconomic status, and tobacco and alcohol consumption
  2. b Never exposed = reference category for all variables presented in Table 2
  3. c A subject was considered “ever” exposed to leather dust if he/she had a non-zero probability of exposure
  4. HNC head and neck cancer