Table 3 Association of para-occupational exposure to pesticides during pregnancy and PON1 genotypes with maternal hypothyroxinemia
Characteristics | All women n = 381(%) | Hypothyroxinemia | p for trend | |||
|---|---|---|---|---|---|---|
Yes n = 207 (%) | No n = 174 (%) | Crude OR (95%CI) | Adjusted OR (95%CI) | |||
Para-occupational exposure to pesticides during pregnancya | ||||||
No | 219 (57.48) | 113 (54.59) | 106 (60.92) | 1.0 | 1.0 | |
Yes | 162 (42.52) | 94 (45.41) | 68 (39.08) | 1.35 (0.88–2.06) | 1.21 (0.75–1.94) | |
PON1 192QR b | ||||||
119 (31.23) | 62 (29.95) | 57 (32.76) | 1.0 | 1.0 | 0.11 | |
QR | 161 (42.26) | 82 (39.61) | 79 (45.40) | 0.89 (0.54–1.45) | 0.87 (0.52–1.47) | |
RR | 101 (26.51) | 63 (30.43) | 38 (21.84) | 1.68 (0.95–2.96) | 1.66 (0.92–2.99) | |
Q allele | 399 (52.30) | 206 (49.75) | 193 (55.39) | 1 | ||
R allele | 363 (47.55) | 208 (50.12) | 155 (44.48) | 1.31 (0.98–1.77) | 1.30 (0.96–1.77) | |
PON155LM*b | ||||||
LL | 195 (51.18) | 93 (44.93) | 102 (58.62) | 1.0 | 1 | 0.001 |
LM | 103 (27.03) | 52 (25.12) | 51 (29.31) | 0.95 (0.58–1.55) | 1.10 (0.65–1.84) | |
MM | 83 (21.78) | 62 (29.95) | 21 (12.07) | 2.47 (1.37–4.45) | 3.01 (1.63–5.57) | |
L allele | 493 (64.58) | 238 (57.35) | 255 (73.18) | 1 | 1 | |
M allele | 269 (35.23) | 176 (42.41) | 93 (26.69) | 1.67 (1.21–2.29) | 1.93 (1.38–2.69) | |
PON1–108CT*b | ||||||
CC | 130 (34.12) | 61 (29.47) | 69 (39.66) | 1.0 | 1 | 0.21 |
CT | 140 (36.75) | 83 (40.10) | 57 (32.76) | 1.36 (0.82–2.24) | 1.36 (0.81–2.31) | |
TT | 111 (29.13) | 63 (30.43) | 48 (27.59) | 1.38 (0.81–2.35) | 1.42 (0.82–2.44) | |
C allele | 400 (52.48) | 205 (49.40) | 195 (55.96) | 1 | 1 | |
T allele | 362 (47.42) | 209 (50.36) | 153 (43.91) | 1.23 (0.92–1.66) | 1.25 (0.92–1.70) | |