Para-occupational exposure to pesticides, PON1 polymorphisms and hypothyroxinemia during the first half of pregnancy in women living in a Mexican floricultural area

Table 4 Models results for the interaction between para-occupational pesticide exposure during pregnancy and PON1 genotypes on maternal hypoythyroxinemia

Maternal PON 1 Genotype		Para-occupational exposure during pregnancy
		Yes		No
	n	Crude OR (95% CI)	Adjusted OR^a (95% CI)	n	Crude OR (95% CI)	Adjusted OR^a (95% CI)
PON1192
QQ	55	1.10 (0.52–2.34)	0.97 (0.44–2.15)	64	1.0	1.0
QR	66	1.27 (0.47–3.43)	1.28 (0.45–3.62)	95	0.81 (0.42–1.56)	0.78 (0.75–1.94)
RR	41	1.61 (0.50–5.14)	1.52 (0.46–5.04)	60	1.41 (0.67–2.96)	1.39 (0.64–3.0)
p for interaction: 0.78
PON155
LL	82	1.13 (0.63–2.04)	1.07 (0.58–1.99)	113	1.0	0.94–1.091.0
LM	45	1.31 (0.48–3.56)	1.15 (0.41–3.25)	58	0.84 (0.44–1.62)	1.02 (0.51–2.05)
MM	35	1.87 (0.55–6.38)	1.49 (0.42–5.27)	48	1.96 (0.94–4.09)	2.59 (1.21–5.57)
p for interaction: 0.82
PON1108
CC	54	0.85 (0.41–1.76)	0.70 (0.32–1.49)	76	1	1.0
CT	62	1.98 (0.72–5.48)	2.11 (0.73–6.10)	78	1.00 (0.52–1.95)	0.98 (0.48–1.49)
TT	46	2.11 (0.71–6.33)	2.49 (0.79–7.81)	65	1.02 (0.51–2.04)	0.96 (0.47–1.98)
p for interaction: 0.23

^aModels were adjusted by: maternal age, gestational age, maternal education, coffee intake, and body mass index

ISSN: 1476-069X