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Table 4 Models results for the interaction between para-occupational pesticide exposure during pregnancy and PON1 genotypes on maternal hypoythyroxinemia

From: Para-occupational exposure to pesticides, PON1 polymorphisms and hypothyroxinemia during the first half of pregnancy in women living in a Mexican floricultural area

Maternal PON 1 Genotype

 

Para-occupational exposure during pregnancy

Yes

No

n

Crude OR (95% CI)

Adjusted ORa (95% CI)

n

Crude OR (95% CI)

Adjusted ORa (95% CI)

PON1192

 QQ

55

1.10 (0.52–2.34)

0.97 (0.44–2.15)

64

1.0

1.0

 QR

66

1.27 (0.47–3.43)

1.28 (0.45–3.62)

95

0.81 (0.42–1.56)

0.78 (0.75–1.94)

 RR

41

1.61 (0.50–5.14)

1.52 (0.46–5.04)

60

1.41 (0.67–2.96)

1.39 (0.64–3.0)

p for interaction: 0.78

PON155

 LL

82

1.13 (0.63–2.04)

1.07 (0.58–1.99)

113

1.0

0.94–1.091.0

 LM

45

1.31 (0.48–3.56)

1.15 (0.41–3.25)

58

0.84 (0.44–1.62)

1.02 (0.51–2.05)

 MM

35

1.87 (0.55–6.38)

1.49 (0.42–5.27)

48

1.96 (0.94–4.09)

2.59 (1.21–5.57)

p for interaction: 0.82

PON1108

 CC

54

0.85 (0.41–1.76)

0.70 (0.32–1.49)

76

1

1.0

 CT

62

1.98 (0.72–5.48)

2.11 (0.73–6.10)

78

1.00 (0.52–1.95)

0.98 (0.48–1.49)

 TT

46

2.11 (0.71–6.33)

2.49 (0.79–7.81)

65

1.02 (0.51–2.04)

0.96 (0.47–1.98)

p for interaction: 0.23

  1. aModels were adjusted by: maternal age, gestational age, maternal education, coffee intake, and body mass index