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Table 1 Odd ratios (ORs) and 95% CI of NIHL– associated SNPs

From: Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility

Genotype Control NIHL P-valuea OR (95% CI)a
Pcdh15/rs11004085
 TT 346 382 0.015 1
 CT 120 88 0.005 0.59 (0.41, 0.85)
 CC 5 3 0.395 0.53 (0.12, 2.31)
 Ptrend    0.005  
 CT/CC 125 91 0.004 0.59 (0.41, 0.84)
EYA4/ rs3777781
 TT 137 166 0.045 1
 AT 236 235 0.116 0.76 (0.54, 1.07)
 AA 96 71 0.015 0.57 (0.36, 0.90)
 Ptrend    0.016  
 AT/AA 332 306 0.047 0.72 (0.52, 0.99)
EYA4/ rs212769
 GG 354 336 0.094 1
 AG 112 129 0.062 1.40 (0.98, 1.98)
 AA 5 8 0.214 2.37 (0.61, 9.23)
 Ptrend    0.033  
 AG/AA 117 137 0.041 1.43 (1.01, 2.02)
MYO1A/rs1552245
 GG 293 308 0.088 1
 AG 164 156 0.032 0.70 (0.51, 0.97)
 AA 14 8 0.448 0.68 (0.25, 1.84)
 Ptrend    0.032  
 AG/AA 178 164 0.027 0.70 (0.51, 0.96)
DFNA5/ rs2521768
 TT 289 305 0.158 1
 CT 155 148 0.249 0.82 (0.60, 1.14)
 CC 27 19 0.089 0.52 (0.25, 1.10)
 Ptrend    0.064  
 CT/CC 182 167 0.122 0.78 (0.57, 1.07)
CDH23/rs2394795
 CC 134 108 0.122 1
 TC 240 244 0.081 1.39 (0.96, 2.02)
 TT 97 120 0.06 1.53 (0.98, 2.38)
 Ptrend    0.058  
 TC/TT 337 364 0.043 1.44 (1.01, 2.05)
CDH23/rs4747192
 CC 168 193 0.213 1
 TC 230 220 0.113 0.77 (0.55, 1.06)
 TT 73 60 0.189 0.73 (0.45, 1.17)
 Ptrend    0.106  
 TC/TT 303 280 0.084 0.76 (0.56, 1.04)
MYO7A/ rs1043421
 TT 252 282 0.16 1
 AT 192 170 0.066 0.74 (0.54, 1.02)
 AA 28 21 0.384 0.73 (0.37, 1.47)
 Ptrend    0.071  
 AT/AA 220 191 0.057 0.74 (0.55, 1.01)
KCNMA1/rs696211
 TT 247 247 0.052 1
 CT 178 194 0.904 0.98 (0.71, 1.35)
 CC 45 31 0.016 0.47 (0.26, 0.87)
 Ptrend    0.080  
 TT + CT 425 441 0.016 0.48 (0.26, 0.87)
KCNMA1/ rs7910544
 GG 343 345 0.175 1
 CG 121 111 0.652 0.92(0.65, 1.31)
 CC 7 16 0.077 2.70(0.90, 8.11)
 Ptrend    0.576  
 GG + CG 7 16 0.070 2.76(0.92,8.26)
CX43/rs3751385
 CC 131 109 0.134 1
 CT 259 265 0.071 1.40 (0.97, 2.01)
 TT 80 99 0.086 1.50 (0.94, 2.39)
 Ptrend    0.081  
 CT/TT 339 364 0.056 1.41 (0.99, 1.99)
GRHL2/ rs471757
 CC 158 167 0.161 1
 CT 208 217 0.889 0.98 (0.69, 1.37)
 TT 105 89 0.078 0.68 (0.45, 1.04)
 Ptrend    0.104  
 CC + CT 366 384 0.062 0.70 (0.48, 1.02)
GRHL2/ rs666026
 TT 244 222 0.147 1
 GT 186 204 0.118 1.29 (0.94, 1.77)
 GG 40 46 0.121 1.55 (0.89, 2.71)
 Ptrend    0.051  
 GT/GG 226 250 0.065 1.33 (0.98, 1.80)
OTOG/ rs7106021
 GG 340 326 0.031 1
 GA 116 136 0.014 1.55(1.09, 2.20)
 AA 14 10 0.485 0.72(0.29, 1.81)
 Ptrend    0.123  
 GA + AA 130 146 0.036 1.43(1.02, 2.00)
  1. a calculated with logistic regression adjusted by age, CNE, smoking, and drinking
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Environmental Health

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