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Table 2 Associations between levels of GRS and risk for NIHL

From: Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility

GRS Control Case Total P-value OR(95% CI)
Median (P25, P75) 8.0 (7.0, 9.0) 9.0 (7.0, 10.0) 8.0 (7.0, 9.0) < 0.001  
GRS subgroup, n (%)
 < 7 84 (17.9) 46 (9.7) 130 (13.8)   1
 7 80 (17.1) 78 (16.5) 158 (16.8) 0.005 2.04 (1.24, 3.38)
 8 120 (25.6) 109 (23.1) 229 (24.3) 0.01 1.85 (1.16, 2.96)
 9 105 (22.4) 102 (21.6) 207 (22.0) 0.005 1.98 (1.23, 3.20)
 10 47 (10.0) 69 (14.6) 116 (12.3) < 0.001 3.22 (1.86, 5.57)
 ≥11 33 (7.0) 68 (14.4) 101 (10.7) < 0.001 5.13 (2.87, 9.16)
P trend < 0.001  
 < 9 284 (60.6) 233 (49.4) 517 (54.9)   1
 ≥9 185 (39.4) 239 (50.6) 424 (45.1) 0.001 1.58 (1.22, 2.04)