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Table 3 Odd ratios (ORs) and 95% CI of NIHL– associated SNPs in the cohort study

From: Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility

Genotype or GRS N NIHL P OR (95% CI)
n %
EYA4/ rs212769
 GG 440 36 8.18   1
 AG 125 13 10.4 0.976 1.01(0.52, 2.19)
 AA 11 4 36.36 0.001 28.27(4.21, 189.85)
 AA vs GG/AG 11/565 4/49 36.36/8.67 0.005 6.710(1.77, 25.41)
KCNMA1/ rs7910544
 GG 424 46 10.85   1
 CG 143 5 3.5 0.017 0.31(0.12, 0.81)
 CC 9 2 22.22 0.157 3.72(0.60, 23.03)
 CC vs CG/GG 9/567 2/51 22.22/8.99 0.027 5.23(1.20, 22.71)
GRSa
 < 7 46 2 4.35   1
 7 75 4 5.33 0.537 1.74(0.30, 10.18)
 8 105 7 6.67 0.425 1.97(0.37, 10.49)
 9 129 15 11.63 0.084 3.99(0.83, 19.12)
 ≥10 211 22 10.43 0.163 2.92(0.65, 13.16)
P trend 0.092  
 < 9 226 13 5.75   1
 ≥9 340 37 10.88 0.038 2.00(1.04,3.86)
  1. a GRS genetic risk score, was calculated as the sum of the risk allele in 14 NIHL-associated SNPs