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Table 3 Odd ratios (ORs) and 95% CI of NIHL– associated SNPs in the cohort study

From: Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility

Genotype or GRS

N

NIHL

P

OR (95% CI)

n

%

EYA4/ rs212769

 GG

440

36

8.18

 

1

 AG

125

13

10.4

0.976

1.01(0.52, 2.19)

 AA

11

4

36.36

0.001

28.27(4.21, 189.85)

 AA vs GG/AG

11/565

4/49

36.36/8.67

0.005

6.710(1.77, 25.41)

KCNMA1/ rs7910544

 GG

424

46

10.85

 

1

 CG

143

5

3.5

0.017

0.31(0.12, 0.81)

 CC

9

2

22.22

0.157

3.72(0.60, 23.03)

 CC vs CG/GG

9/567

2/51

22.22/8.99

0.027

5.23(1.20, 22.71)

GRSa

 < 7

46

2

4.35

 

1

 7

75

4

5.33

0.537

1.74(0.30, 10.18)

 8

105

7

6.67

0.425

1.97(0.37, 10.49)

 9

129

15

11.63

0.084

3.99(0.83, 19.12)

 ≥10

211

22

10.43

0.163

2.92(0.65, 13.16)

P trend

0.092

 

 < 9

226

13

5.75

 

1

 ≥9

340

37

10.88

0.038

2.00(1.04,3.86)

  1. a GRS genetic risk score, was calculated as the sum of the risk allele in 14 NIHL-associated SNPs