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Table 2 Arsenic exposure in mothers and newborns

From: Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study

Parameters

Maternal arsenic exposure by toenail As

p-value b

Low (<  0.5 mg/g)

Medium (0.5–1 mg/g)

High (> 1 mg/g)

(n = 82)

(n = 57)

(n = 66)

Maternal toenail As (μg/g)

0.30 ± 0.01b

0.73 ± 0.02***

1.92 ± 0.13***, ###

0.000

0.29 (0.10–0.49)c

0.71 (0.50–0.99)

1.55 (1.00–6.07)

 

Maternal urinary As

 Total arsenic (μg/L)

28.20 ± 2.27

40.05 ± 3.69*

60.71 ± 6.23***,##

0.000

25.26 (2.16–130.23)

29.26 (8.48–111.05)

50.55 (10.03–328.90)

 

 Total arsenic (μg/g creatinine)

57.46 ± 4.25

67.95 ± 4.58

93.91 ± 7.42***, ##

0.013

46.68 (1.57–162.39)

61.88 (13.39–166.66)

75.59 (16.57–339.59)

 

Urinary As metabolites

 iAs (μg/L)

3.48 ± 0.34

3.38 ± 0.32

4.71 ± 0.64**, #

0.014

2.96(nd-17.13)

2.96(nd-9.67)

3.05 (0.68–38.26)

 

 MMA (μg/L)

4.60 ± 0.43

5.57 ± 0.51*

7.74 ± 0.81***

0.000

3.98(nd-18.42)

4.30(nd-16.82)

6.03 (0.13–40.13)

 

 DMA (μg/L)

32.90 ± 2.84

34.69 ± 3.34

47.14 ± 4.90**

0.010

25.26(1.59–140.92)

26.28(9.08–115.14)

36.17 (5.04–247.81)

 

Umbilical cord blood As (μg/L)

1.70 ± 0.09

2.09 ± 0.13

2.46 ± 0.21**

0.000

1.50 (0.17–4.60)

1.78 (0.85–6.22)

2.05 (0.89–9.72)

 
  1. aStatistically significant difference among groups at p < 0.05 by One-way ANOVA are highlighted in bold
  2. Values are expressed as mean ± SE (b) and median (minimum - maximum) (c)
  3. *, **, *** Statistically significant difference from corresponding low-exposed group at p < 0.05, < 0.01 and < 0.001, respectively by Mann-Whitney U test
  4. #, ##, ###Statistically significant difference from corresponding medium-exposed group at p < 0.05, < 0.01 and < 0.001, respectively by Mann-Whitney U test