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Table 3 DNA damage in cord blood of newborns exposed to arsenic in utero

From: Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study

Types of DNA damageMaternal arsenic exposure by toenail AsFDR- adjusted p-valuea
Low (<  0.5 μg/g)Medium (0.5–1 μg/g)High (> 1 μg/g)
8-OHdG (ng/mL)0.24 ± 0.01b0.26 ± 0.010.28 ± 0.01**0.010
0.24 (0.13–0.44)c0.26 (0.18–0.49)0.26 (0.19–0.55) 
(n = 81)(n = 52)(n = 61) 
8-Nitroguanine (ng/mL)157.66 ± 13.85183.21 ± 17.90229.94 ± 23.34*0.032
117.20 (13.59–426.51)154.99 (22.51–540.60)178.77 (26.73–831.84) 
(n = 78)(n = 53)(n = 58) 
DNA strand breaks
 Tail length (μm)2.37 ± 0.082.81 ± 0.10**3.04 ± 0.09***0.000
2.38 (0.65–4.11)2.74 (1.13–4.03)2.98 (1.69–4.92) 
(n = 73)(n = 48)(n = 54) 
 Olive tail moment (μm)d0.20 ± 0.010.24 ± 0.01**0.27 ± 0.01***0.000
0.19 (0.07–0.39)0.22 (0.07–0.44)0.26 (0.11–0.49) 
(n = 73)(n = 48)(n = 54) 
 %DNA in tail1.36 ± 0.061.62 ± 0.08*1.94 ± 0.10***, ##0.000
1.28 (0.53–3.00)1.51 (0.37–2.88)1.82 (0.48–4.05) 
(n = 73)(n = 48)(n = 54) 
  1. aThe raw p-values were subjected to multiple testing correction using FDR-adjusted p-value; Statistically significant difference among groups at p < 0.05 by One-way ANOVA are highlighted in bold
  2. Values are expressed as mean ± SE (b) and Median (minimum - maximum) (c)
  3. *, **, *** Statistically significant difference from corresponding low- exposed group at p < 0.05, < 0.01 and < 0.001, respectively by Mann-Whitney U test
  4. ##Statistically significant difference from corresponding medium-exposed group at p < 0.01 by Mann-Whitney U test
  5. dOlive tail moment is the product of the tail length and the fraction of total DNA in the tail