Skip to main content

Table 4 Micronucleus frequency in cord blood of newborns exposed to arsenic in utero

From: Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study

Parameters

Maternal arsenic exposure by toenail As

FDR- adjusted p-valuea

Low (<  0.5 μg/g)

Medium (0.5–1 μg/g)

High (> 1 μg/g)

MN in mononucleated cells (per 1000 cells)

0.16 ± 0.04b

0.48 ± 0.08**

0.60 ± 0.09***

0.000

0.00 (0.00–1.00)c

0.00 (0.00–2.00)

1.00 (0.00–2.00)

 

(n = 70)

(n = 46)

(n = 52)

 

MN in binucleated cells (per 1000 cells)

1.96 ± 0.21

2.26 ± 0.34

3.08 ± 0.41*

0.037

2.00 (0.00–12.0)

2.00 (0.00–13.0)

2.00 (0.00–15.0)

 

(n = 70)

(n = 46)

(n = 52)

 

Nuclear division index (NDI)

1.94 ± 0.01

1.97 ± 0.02

1.94 ± 0.01

0.117

1.92 (1.75–2.19)

1.97 (1.79–2.75)

1.95 (1.59–2.07)

 

(n = 70)

(n = 46)

(n = 52)

 
  1. aThe raw p-values were subjected to multiple testing correction using FDR-adjusted p-value; Statistically significant difference among groups at p < 0.05 by One-way ANOVA are highlighted in bold
  2. Values are expressed as mean ± SE (b) and Median (minimum - maximum) (c)
  3. *, **, *** Statistically significant difference from corresponding low- exposed group at p < 0.05, < 0.01 and < 0.001, respectively by Mann-Whitney U test