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Table 5 Univarite analysis of associations among the study parameters

From: Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study

 Coefficient β (95% CI)
DNA base damageDNA strand breaksMicronucleus frequencyArsenic concentration
8-OHdG8-nitroguanineTail lengthOlive tail moment%DNA in tailMononucleatedBinucleatedUrine(μg/g creatinine)Cord bloodToenail
Arsenic exposure
 Maternal toenail0.068**0.244**0.112***0.083*0.131**0.698**-0.0450.225***0.126** 
(0.023,0.133)(0.078,0.410)(0.056,0.168)(0.017,0.149)(0.056,0.207)(0.272,1.124)(-0.167,0.077)(0.113,0.336)(0.043,0.209) 
 Maternal urine
  Total As0.003-0.0170.0580.135**0.100*0.3780.128   
(-0.054,0.061)(-0.229,0.196)(-0.014,0.129)(0.051,0.220)(0.004,0.197)(-0.166,0.922)(-0.028,0.084)   
  iAs-0.0210.155-0.0090.0430.02-0.0850.051-0.0540.007-0.184
(-0.079,0.037)(-0.060,0.371)(-0.081,0.064)(-0.043,0.129)(-0.078,0.118)(-0.637,0.468)(-0.107,0.209)(-0.205,0.097)(-0.103,0.117)(-0.375,0.007)
  MMA0.0190.1410.0100.0470.0390.4960.115-0.1070.0540.215*
(-0.039,0.077)(-0.075,0.356)(-0.063,0.082)(-0.039,0.133)(-0.059,0.137)(-0.056,1.048)(-0.043,0.273)(-0.257,0.043)(-0.056,0.163)(0.025,0.405)
  DMA-0.01-0.2380.011-0.057-0.025-0.146-0.0700.445***-0.0970.003
(-0.075,0.055)(-0.475,0.003)(-0.070,0.092)(-0.153,0.039)(-0.135,0.084)(-0.763,0.470)(-0.246,0.106)(0.290,0.600)(-0.218,0.025)(-0.212,0.218)
 Cord blood-0.056-0.0860.192***0.256***0.244***0.4560.774***0.042  
(-0.135,0.023)(-0.379,0.206)(0.094,0.290)(0.140,0.373)(0.111,0.377)(-0.292,1.204)(0.560,0.988)(-0.163,0.246)  
DNA damage
 8-OHdG 0.0250.082-0.1190.0400.016-0.035   
 (-0.021,0.071)(-0.083,0.247)(-0.356,0.119)(-0.148,0.229)(-0.007,0.038)(-0.096,0.026)   
 8-nitroguanine  0.0430.1700.459-0.008-0.063   
  (-0.563,0.649)(-0.700,1.040)(-0.226,1.144)(-0.091,0.075)(-0.286,0.160)   
DNA strand breaks
 Tail length   0.432***0.0630.0020.064*   
   (0.201,0.663)(-0.128,0.255)(-0.021,0.026)(0.003,0.125)   
 Olive tail moment    0.574***0.033***0.008   
    (0.482,0.666)(0.018,0.048)(-0.035,0.051)   
 %DNA in tail     0.0030.019   
     (-0.018,0.023)(-0.036,0.074)   
  1. β represents standardized coefficient; 95% CI represents 95% confidence interval (CI)
  2. Olive tail moment is the product of the tail length and the fraction of total DNA in the tail
  3. *, **,*** Statistically significant association at p < 0.05, p < 0.01 and p < 0.001, respectively