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Table 6 Multivariate regression analyses between arsenic exposure and early genotoxic effects in newborns

From: Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study

 Coefficient β [adjusted p-value] (95%CI)
DNA base damageDNA strand breaksMicronucleus frequency
8-OHdG8-NitroguanineTail LengthOlive Mom.%DNA in tailMononucleatedBinucleated
Toenail As0.234 [0.010]0.210 [0.031]0.360 [0.000]0.192 [0.000]0.273 [0.000]0.325 [0.000]-0.029 [0.958]
(μg/L)(0.089, 0.379)(0.064, 0.356)(0.221, 0.499)(0.045, 0.339)(0.124, 0.422)(0.177, 0.472)(-0.175, 0.118)
Urinary Total As0.003 [0.974]-0.063 [0.518]0.142 [0.140]0.232 [0.000]0.165 [0.073]0.100 [0.220]0.090 [0.146]
(μg/g creatinine)(-0.153, 0.158)(-0.219, 0.094)(-0.001, 0.285)(0.089, 0.376)(0.020, 0.310)(-0.056, 0.256)(-0.052, 0.232)
Urinary iAs-0.038 [0.974]0.109 [0.423]0.021 [0.781]0.093 [0.112]0.060 [0.359]-0.034 [0.339]0.050 [0.146]
(μg/L)(-0.183, 0.107)(-0.037, 0.255)(-0.114, 0.156)(-0.042, 0.228)(-0.077, 0.197)(-0.213, 0.144)(-0.119, 0.219)
Urinary MMA0.012 [0.974]0.076 [0.518]0.054 [0.538]0.087 [0.027]0.073 [0.268]0.163 [0.091]0.153 [0.114]
(μg/L)(-0.137, 0.161)(-0.074, 0.226)(-0.085, 0.192)(-0.052, 0.226)(-0.068, 0.214)(0.016, 0.311)(0.011, 0.295)
Urinary DMA-0.006 [0.974]-0.060 [0.518]0.085 [0.538]0.003 [0.056]0.029 [0.375]-0.012 [0.255]-0.011 [0.227]
(μg/L)(-0.155, 0.143)(-0.209, -0.090)(-0.053, 0.223)(-0.148, 0.153)(-0.123, 0.181)(-0.208, 0.183)(-0.199, 0.177)
Cord blood-0.105 [0.503]-0.026 [0.732]0.270 [0.001]0.316 [0.000]0.264 [0.001]0.094 [0.255]0.519 [0.000]
(μg/L)(-0.254, 0.044)(-0.177, 0.125)(0.131, 0.409)(0.178, 0.454)(0.125, 0.404)(-0.054, 0.242)(0.380, 0.657)
  1. Model was adjusted for the covariates including age, BMI, education, occupation, gestational age of sample collection during pregnancy (urine and nail samples) and baby delivery (cord blood sample)
  2. The raw p-values were subjected to multiple testing corrections using FDR-adjusted p-value and the statistically significant are highlighted in bold
  3. β represents standardized coefficient; 95% CI represents 95% confidence interval (CI)
  4. Olive tail moment is the product of the tail length and the fraction of total DNA in the tail