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Table 6 Multivariate regression analyses between arsenic exposure and early genotoxic effects in newborns

From: Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study

 

Coefficient β [adjusted p-value] (95%CI)

DNA base damage

DNA strand breaks

Micronucleus frequency

8-OHdG

8-Nitroguanine

Tail Length

Olive Mom.

%DNA in tail

Mononucleated

Binucleated

Toenail As

0.234 [0.010]

0.210 [0.031]

0.360 [0.000]

0.192 [0.000]

0.273 [0.000]

0.325 [0.000]

-0.029 [0.958]

(ÎĽg/L)

(0.089, 0.379)

(0.064, 0.356)

(0.221, 0.499)

(0.045, 0.339)

(0.124, 0.422)

(0.177, 0.472)

(-0.175, 0.118)

Urinary Total As

0.003 [0.974]

-0.063 [0.518]

0.142 [0.140]

0.232 [0.000]

0.165 [0.073]

0.100 [0.220]

0.090 [0.146]

(ÎĽg/g creatinine)

(-0.153, 0.158)

(-0.219, 0.094)

(-0.001, 0.285)

(0.089, 0.376)

(0.020, 0.310)

(-0.056, 0.256)

(-0.052, 0.232)

Urinary iAs

-0.038 [0.974]

0.109 [0.423]

0.021 [0.781]

0.093 [0.112]

0.060 [0.359]

-0.034 [0.339]

0.050 [0.146]

(ÎĽg/L)

(-0.183, 0.107)

(-0.037, 0.255)

(-0.114, 0.156)

(-0.042, 0.228)

(-0.077, 0.197)

(-0.213, 0.144)

(-0.119, 0.219)

Urinary MMA

0.012 [0.974]

0.076 [0.518]

0.054 [0.538]

0.087 [0.027]

0.073 [0.268]

0.163 [0.091]

0.153 [0.114]

(ÎĽg/L)

(-0.137, 0.161)

(-0.074, 0.226)

(-0.085, 0.192)

(-0.052, 0.226)

(-0.068, 0.214)

(0.016, 0.311)

(0.011, 0.295)

Urinary DMA

-0.006 [0.974]

-0.060 [0.518]

0.085 [0.538]

0.003 [0.056]

0.029 [0.375]

-0.012 [0.255]

-0.011 [0.227]

(ÎĽg/L)

(-0.155, 0.143)

(-0.209, -0.090)

(-0.053, 0.223)

(-0.148, 0.153)

(-0.123, 0.181)

(-0.208, 0.183)

(-0.199, 0.177)

Cord blood

-0.105 [0.503]

-0.026 [0.732]

0.270 [0.001]

0.316 [0.000]

0.264 [0.001]

0.094 [0.255]

0.519 [0.000]

(ÎĽg/L)

(-0.254, 0.044)

(-0.177, 0.125)

(0.131, 0.409)

(0.178, 0.454)

(0.125, 0.404)

(-0.054, 0.242)

(0.380, 0.657)

  1. Model was adjusted for the covariates including age, BMI, education, occupation, gestational age of sample collection during pregnancy (urine and nail samples) and baby delivery (cord blood sample)
  2. The raw p-values were subjected to multiple testing corrections using FDR-adjusted p-value and the statistically significant are highlighted in bold
  3. β represents standardized coefficient; 95% CI represents 95% confidence interval (CI)
  4. Olive tail moment is the product of the tail length and the fraction of total DNA in the tail
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Environmental Health

ISSN: 1476-069X